Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | EDNRA | P25101 | 3/20 | 0.42 |
| ▸ | EDNRB | P24530 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.38 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.38 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.37 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9043741 | 0.90 | LMNA (0.56) | LMNAKDM4EMAPK1HSD17B10SMN1; SMN2 | |
| SCHEMBL9045520 | 0.88 | EDNRA (0.51) | LMNASMN1; SMN2ALDH1A1MAPTEDNRA | |
| SCHEMBL9493462 | 0.87 | EDNRB (0.44) | LMNAKDM4EMAPK1HSD17B10SMN1; SMN2 | |
| SCHEMBL9046378 | 0.85 | EDNRA (0.57) | ALDH1A1MAPTEDNRAEDNRBTSHR | |
| SCHEMBL9044642 | 0.84 | EDNRA (0.63) | EDNRAEDNRB | |
| SCHEMBL9046700 | 0.84 | EDNRA (0.49) | ALDH1A1MAPTEDNRAEDNRBKIT | |
| SCHEMBL9677292 | 0.83 | LMNA (0.46) | LMNAKDM4EMAPK1HSD17B10SMN1; SMN2 | |
| SCHEMBL9043808 | 0.83 | EDNRB (0.47) | KDM4ESMN1; SMN2ALDH1A1MAPTEDNRA | |
| SCHEMBL9047883 | 0.81 | EDNRA (0.45) | LMNAMAPK1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL9047430 | 0.81 | EDNRA (0.47) | LMNAKDM4EHSD17B10ALDH1A1EDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510526-B1 | Use of sulfonamides as drug and new sulfonamides | HOFFMANN LA ROCHE (CH) | 1996-12-04 | — | — | EP | disclosed |
| EP-0723533-A1 | 1N-ALKYL-N-ARYLPYRIMIDINAMINES AND DERIVATIVES THEREOF | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-07-31 | — | — | EP | disclosed |
| US-5270313-A | Treatment of circulatory disorders | HOFFMANN-LA ROCHE INC. (US) | 1993-12-14 | — | — | US | disclosed |
| EP-0510526-A1 | Use of sulfonamides as drug and new sulfonamides | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1992-10-28 | — | — | EP | disclosed |