Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 4/20 | 0.51 |
| ▸ | EDNRB | P24530 | 3/20 | 0.51 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9046378 | 0.96 | EDNRA (0.57) | EDNRAEDNRBKITALDH1A1MAPT | |
| SCHEMBL9046700 | 0.95 | EDNRA (0.49) | EDNRAEDNRBKITALDH1A1MAPT | |
| SCHEMBL9043808 | 0.94 | EDNRB (0.47) | EDNRAEDNRBKITALDH1A1MAPT | |
| SCHEMBL9053125 | 0.92 | EDNRA (0.47) | EDNRAEDNRBKITMAPTKMT2A | |
| SCHEMBL9047430 | 0.92 | EDNRA (0.47) | EDNRAEDNRBKITALDH1A1ESR1 | |
| SCHEMBL9047883 | 0.92 | EDNRA (0.45) | EDNRAEDNRBKITALDH1A1MAPT | |
| SCHEMBL9046552 | 0.91 | EDNRA (0.57) | EDNRAEDNRBKITMEN1KMT2A | |
| SCHEMBL9045307 | 0.88 | LMNA (0.43) | EDNRAEDNRBKITALDH1A1MAPT | |
| SCHEMBL9045052 | 0.86 | MEN1 (0.55) | EDNRAEDNRBALDH1A1MAPTMEN1 | |
| SCHEMBL9492453 | 0.83 | EDNRA (0.47) | EDNRAEDNRBKITALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510526-B1 | Use of sulfonamides as drug and new sulfonamides | HOFFMANN LA ROCHE (CH) | 1996-12-04 | — | — | EP | disclosed |
| US-5270313-A | Treatment of circulatory disorders | HOFFMANN-LA ROCHE INC. (US) | 1993-12-14 | — | — | US | disclosed |
| EP-0510526-A1 | Use of sulfonamides as drug and new sulfonamides | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1992-10-28 | — | — | EP | disclosed |