Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 4/20 | 0.45 |
| ▸ | EDNRB | P24530 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9045520 | 0.92 | EDNRA (0.51) | EDNRAEDNRBALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL9046378 | 0.89 | EDNRA (0.57) | EDNRAEDNRBALDH1A1MAPTKIT | |
| SCHEMBL9046700 | 0.87 | EDNRA (0.49) | EDNRAEDNRBALDH1A1MAPTKIT | |
| SCHEMBL9043808 | 0.86 | EDNRB (0.47) | EDNRAEDNRBALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL9046082 | 0.86 | ALDH1A1 (0.56) | EDNRAEDNRBALDH1A1MAPTLMNA | |
| SCHEMBL9494268 | 0.85 | EDNRA (0.56) | EDNRAEDNRBKITKMT2AMEN1 | |
| SCHEMBL9047430 | 0.84 | EDNRA (0.47) | EDNRAEDNRBALDH1A1LMNAKIT | |
| SCHEMBL9053125 | 0.84 | EDNRA (0.47) | EDNRAEDNRBMAPTSMN1; SMN2LMNA | |
| SCHEMBL9046552 | 0.83 | EDNRA (0.57) | EDNRAEDNRBKITMMP2MMP9 | |
| SCHEMBL9047331 | 0.83 | EDNRA (0.68) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510526-B1 | Use of sulfonamides as drug and new sulfonamides | HOFFMANN LA ROCHE (CH) | 1996-12-04 | — | — | EP | disclosed |
| US-5270313-A | Treatment of circulatory disorders | HOFFMANN-LA ROCHE INC. (US) | 1993-12-14 | — | — | US | disclosed |
| EP-0510526-A1 | Use of sulfonamides as drug and new sulfonamides | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1992-10-28 | — | — | EP | disclosed |