Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 2/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 7/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 7/20 | 0.44 |
| ▸ | LIG1 | P18858 | 1/20 | 0.43 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | ULK1 | O75385 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8501275 | 0.78 | PDGFRB (0.50) | PDGFRBPDGFRAGRIN1GRIN2BLIG1 | |
| SCHEMBL6517572 | 0.72 | PARP1 (0.50) | GRIN1GRIN2BPARP1KITALDH1A1 | |
| SCHEMBL2851692 | 0.72 | ERN1 (0.51) | PDGFRBPDGFRAERN1PARP1ALDH1A1 | |
| SCHEMBL5126305 | 0.72 | MAP4K4 (0.54) | PDGFRBPDGFRAERN1PARP1ALDH1A1 | |
| SCHEMBL29636083 | 0.70 | GSK3A (0.66) | PDGFRBPDGFRAGRIN1GRIN2BLIG1 | |
| SCHEMBL1039269 | 0.70 | KDM4E (0.51) | PDGFRBPDGFRAERN1ALDH1A1HPGD | |
| SCHEMBL29956595 | 0.70 | KDM4E (0.51) | PDGFRBPDGFRAERN1ALDH1A1HPGD | |
| SCHEMBL2731348 | 0.70 | KDM4E (0.58) | PDGFRBPDGFRAALDH1A1HPGD | |
| SCHEMBL12127570 | 0.70 | BRD4 (0.65) | PDGFRBPDGFRACDK1RIPK1 | |
| SCHEMBL5716791 | 0.68 | RIPK1 (0.48) | ERN1ULK1CCNB2CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705261-A1 | ANTIPROLIFERATIVE NAPHTHYRIDINES | LABORATOIRES UPSA (FR) | 1996-04-10 | — | — | EP | disclosed |
| WO-1995000513-A1 | ANTIPROLIFERATIVE NAPHTHYRIDINES | LABORATOIRES UPSA (FR) | 1995-01-05 | — | — | WO | disclosed |