Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 3/20 | 0.37 |
| ▸ | CDK2 | P24941 | 3/20 | 0.37 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.35 |
| ▸ | GLO1 | Q04760 | 3/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | CKS1B | P61024 | 2/20 | 0.33 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.33 |
| ▸ | ITK | Q08881 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9048641 | 0.76 | CCNE1 (0.54) | CCNE1CDK2CCNE2GRM4ITK | |
| SCHEMBL11368649 | 0.71 | GRM4 (0.56) | CCNE1CDK2CCNE2HSD17B10LMNA | |
| SCHEMBL11362219 | 0.68 | LMNA (0.38) | GLO1ALOX15HTTHSD17B10LMNA | |
| SCHEMBL6501402 | 0.68 | PIK3CB (0.39) | HSD17B10LMNANPC1ALDH1A1 | |
| SCHEMBL1607000 | 0.66 | MYC (0.48) | CDK2ALOX15HTTNPC1RAB9A | |
| SCHEMBL9426024 | 0.66 | CCNE1 (0.47) | CCNE1CDK2CCNE2ALDH1A1 | |
| SCHEMBL14144950 | 0.66 | TDP1 (0.39) | HTTHSD17B10LMNANPC1ALDH1A1 | |
| SCHEMBL3547268 | 0.65 | NTRK1 (0.37) | NTRK1GRM4 | |
| SCHEMBL5323412 | 0.65 | HCAR2 (0.50) | CCNE1CDK2HSD17B10LMNANPC1 | |
| SCHEMBL12256025 | 0.62 | GLO1 (0.48) | GLO1ALOX15HTTLMNACKS1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0412404-B1 | Thiazole derivatives, processes for production thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1996-01-31 | — | — | EP | disclosed |
| CN-1027370-C | Process for preparing thiazole derivatives | FUJISAWA FARMACEUTICAL CO LTD (JP) | 1995-01-11 | — | — | CN | disclosed |
| US-5369107-A | Thiazole derivatives, processes for production thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-11-29 | — | — | US | disclosed |
| US-5256675-A | Antirheumatic agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-10-26 | — | — | US | disclosed |
| CN-1049337-A | Thiazole derivative prepares their method, and the medicinal compositions that contains them | FUJISAWA PHARMACEUTICAL CO (JP) | 1991-02-20 | — | — | CN | disclosed |
| EP-0412404-A2 | Thiazole derivatives, processes for production thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-02-13 | — | — | EP | disclosed |