Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 6/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CFTR | P13569 | 6/20 | 0.34 |
| ▸ | F2RL1 | P55085 | 2/20 | 0.33 |
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9045322 | 0.88 | TAAR1 (0.38) | TAAR1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL198944 | 0.87 | GRM5 (0.35) | — | |
| SCHEMBL11507567 | 0.85 | TAAR1 (0.45) | TAAR1MEN1KMT2ASMN1; SMN2CFTR | |
| SCHEMBL9046397 | 0.82 | TAAR1 (0.34) | TAAR1 | |
| SCHEMBL9046269 | 0.82 | GABRA1 (0.38) | TAAR1 | |
| SCHEMBL3757556 | 0.81 | TAAR1 (0.54) | TAAR1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL12719467 | 0.80 | TAAR1 (0.43) | TAAR1MEN1KMT2ASMN1; SMN2CFTR | |
| SCHEMBL9045705 | 0.79 | SMN1; SMN2 (0.35) | TAAR1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL198620 | 0.78 | LIPG (0.39) | HTT | |
| SCHEMBL9046154 | 0.78 | TAAR1 (0.42) | TAAR1MEN1KMT2ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690854-A1 | 1-PHENYL-IMIDAZOL-2-ONE BIPHENYLMETHYL COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1996-01-10 | — | — | EP | claimed |
| EP-0690854-A1 | 1-PHENYL-IMIDAZOL-2-ONE BIPHENYLMETHYL COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1996-01-10 | — | — | EP | disclosed |
| EP-0664802-A1 | N-ARYLHETEROARYLALKYL 1-PHENYL-IMIDAZOL-2-ONE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1995-08-02 | — | — | EP | disclosed |
| WO-1994008990-A1 | N-ARYLHETEROARYLALKYL 1-PHENYL-IMIDAZOL-2-ONE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1994-04-28 | — | — | WO | disclosed |