Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | SELE | P16581 | 1/20 | 0.38 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7019066 | 0.89 | NPSR1 (0.56) | NPSR1ALDH1A1HPGDSMN1; SMN2KMT2A | |
| SCHEMBL9044351 | 0.83 | NPSR1 (0.46) | NPSR1ALDH1A1HPGDSMN1; SMN2NPC1 | |
| SCHEMBL9046748 | 0.80 | KDM4E (0.48) | NPSR1ALDH1A1HPGDSMN1; SMN2NPC1 | |
| SCHEMBL6844296 | 0.80 | NPSR1 (0.47) | NPSR1ALDH1A1HPGDGAAMAPK1 | |
| SCHEMBL21708066 | 0.76 | NPSR1 (0.43) | NPSR1ALDH1A1HPGDMEN1GAA | |
| SCHEMBL10998213 | 0.75 | MAPT (0.46) | ALDH1A1HPGDGAAMAPK1KDM4E | |
| SCHEMBL5079627 | 0.73 | ALDH1A1 (0.50) | NPSR1ALDH1A1HPGDSMN1; SMN2NPC1 | |
| SCHEMBL7480184 | 0.73 | GABRP (0.45) | ALDH1A1HPGDGAAMAPK1KDM4E | |
| SCHEMBL11579997 | 0.73 | MAPT (0.44) | ALDH1A1HPGDNPC1RAB9AMEN1 | |
| SCHEMBL11578876 | 0.73 | MAPT (0.49) | ALDH1A1HPGDMEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0443568-B1 | Fused thiophene derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1996-06-12 | — | — | EP | disclosed |
| US-5284661-A | 4-Oxo-7-(biphenyl-4-yl)thieno(2,3-b)pyridines as antagonist of angiotensin II; hypertensive agents, cardiovascular disorders and strokes | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-02-08 | — | — | US | disclosed |
| EP-0443568-A1 | Fused thiophene derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-08-28 | — | — | EP | disclosed |