Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.52 |
| ▸ | GAK | O14976 | 1/20 | 0.45 |
| ▸ | TNF | P01375 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
| ▸ | FBP1 | P09467 | 1/20 | 0.44 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11046526 | 0.83 | SMARCA2 (0.66) | EGFRKDR | |
| SCHEMBL3946380 | 0.82 | HTR3E (0.55) | EGFRTNFGRM4KDR | |
| SCHEMBL1415496 | 0.82 | ALDH1A1 (0.52) | GRM4 | |
| SCHEMBL8873583 | 0.79 | EGFR (0.52) | EGFRGAKTNFABCG2RAPGEF4 | |
| SCHEMBL27996985 | 0.79 | EGFR (0.52) | EGFRGAKTNF | |
| SCHEMBL20748625 | 0.79 | KDM4E (0.56) | EGFRGRM4RAPGEF4 | |
| SCHEMBL29961149 | 0.79 | RAPGEF4 (0.61) | EGFRABCG2RAPGEF4KDR | |
| SCHEMBL29961547 | 0.79 | RAPGEF4 (0.61) | EGFRABCG2RAPGEF4KDR | |
| SCHEMBL1687027 | 0.79 | RAPGEF4 (0.61) | EGFRABCG2RAPGEF4KDR | |
| SCHEMBL8470618 | 0.78 | EGFR (0.51) | EGFRABCG2RAPGEF4KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0742717-A1 | BICYCLIC COMPOUNDS CAPABLE OF INHIBITING TYROSINE KINASES OF THE EPIDERMAL GROWTH FACTOR RECEPTOR FAMILY | WARNER-LAMBERT COMPANY (US) | 1996-11-20 | — | — | EP | disclosed |