Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 7/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.45 |
| ▸ | HTR2A | P28223 | 4/20 | 0.42 |
| ▸ | HTR7 | P34969 | 4/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | CCR2 | P41597 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9479252 | 0.99 | FLT3 (0.47) | FLT3P2RX7ROCK2ROCK1HTR2A | |
| SCHEMBL9049718 | 0.88 | P2RX7 (0.46) | P2RX7ROCK2ROCK1HTR2AHTR7 | |
| Hydrochloric Acid SCHEMBL9478386 | 0.87 | P2RX7 (0.46) | P2RX7ROCK2ROCK1HTR2AHTR7 | |
| Hydrochloric Acid SCHEMBL9477834 | 0.87 | HTR2A (0.45) | FLT3P2RX7ROCK2ROCK1HTR2A | |
| SCHEMBL9478929 | 0.86 | HTR1A (0.48) | P2RX7ROCK2ROCK1HTR2AHTR7 | |
| Hydrochloric Acid SCHEMBL9477785 | 0.84 | ROCK2 (0.44) | FLT3P2RX7ROCK2ROCK1HTR2A | |
| Hydrochloric Acid SCHEMBL9480122 | 0.84 | P2RX7 (0.44) | P2RX7ROCK2ROCK1HTR2AHTR7 | |
| Hydrochloric Acid SCHEMBL9477689 | 0.83 | P2RX7 (0.44) | P2RX7ROCK2ROCK1 | |
| Hydrochloric Acid SCHEMBL9477303 | 0.83 | P2RX7 (0.43) | P2RX7ROCK2ROCK1HTR2AHTR7 | |
| SCHEMBL9046682 | 0.83 | P2RX7 (0.45) | P2RX7ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526342-B1 | Isoquinolin-5yl-sulphonamides, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1996-12-04 | — | — | EP | claimed |
| US-5208243-A | Analgesics | ADIR ET COMPAGNIE (FR) | 1993-05-04 | — | — | US | claimed |