Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EED | O75530 | 8/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | DAO | P14920 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | SCN1A | P35498 | 1/20 | 0.30 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.30 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18243554 | 0.86 | ALDH1A1 (0.33) | TAAR1ALDH1A1 | |
| SCHEMBL6130256 | 0.86 | TAAR1 (0.42) | TAAR1GAADAOKDM4EALDH1A1 | |
| SCHEMBL6518274 | 0.81 | EED (0.36) | EEDTAAR1GAAKDM4EALDH1A1 | |
| SCHEMBL20558278 | 0.79 | EED (0.40) | EEDTAAR1GAAKDM4EALDH1A1 | |
| SCHEMBL9045995 | 0.78 | ALDH1A1 (0.43) | TAAR1ALDH1A1 | |
| SCHEMBL9046621 | 0.78 | ACHE (0.43) | EEDTAAR1GAADAOKDM4E | |
| SCHEMBL27577860 | 0.78 | TAAR1 (0.39) | EEDTAAR1GAADAOKDM4E | |
| SCHEMBL20558456 | 0.78 | TAAR1 (0.59) | EEDTAAR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL9049748 | 0.77 | TAAR1 (0.41) | TAAR1GAAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL3761954 | 0.77 | TAAR1 (0.63) | TAAR1GAADAOKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690854-A1 | 1-PHENYL-IMIDAZOL-2-ONE BIPHENYLMETHYL COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1996-01-10 | — | — | EP | claimed |
| EP-0690854-A1 | 1-PHENYL-IMIDAZOL-2-ONE BIPHENYLMETHYL COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1996-01-10 | — | — | EP | disclosed |