Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8828159 | 0.88 | HTR2A (0.47) | TRPM8HTR2AHTR2CHTR2BHTR1A | |
| SCHEMBL9468388 | 0.83 | KDM4E (0.50) | KDM4EHTR2AHTR2CHTR2BHPGD | |
| SCHEMBL8828377 | 0.79 | CYP3A4 (0.50) | ALDH1A1LMNAMAPT | |
| SCHEMBL9046497 | 0.77 | HTR2A (0.46) | HTR2AHTR2CHTR2BHTR1ASLC6A4 | |
| SCHEMBL8828424 | 0.76 | SMPD1 (0.50) | KDM4EHTR2AHTR2CHTR2BALDH1A1 | |
| SCHEMBL8828132 | 0.75 | MAPT (0.44) | KDM4EHPGDALDH1A1MAPT | |
| SCHEMBL9044808 | 0.73 | HTR2A (0.49) | HTR2AHTR2CHTR2BHTR1ASLC6A4 | |
| SCHEMBL8828540 | 0.73 | HTR2A (0.49) | HTR2AHTR2CHTR2BHTR1ASLC6A4 | |
| SCHEMBL8828215 | 0.73 | CYP3A4 (0.41) | HTR2AHTR2CHTR2BALDH1A1LMNA | |
| SCHEMBL8828324 | 0.72 | HTR2A (0.48) | HTR2AHTR2CHTR2BHTR1ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0344577-B1 | Butenoic or propenoic acid derivatives | EISAI CO LTD (JP) | 1996-10-09 | — | — | EP | disclosed |
| EP-0344577-A2 | Butenoic or propenoic acid derivatives | Eisai Co., Ltd. (JP) | 1989-12-06 | — | — | EP | disclosed |