Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 14/20 | 0.46 |
| ▸ | HTR2B | P41595 | 14/20 | 0.46 |
| ▸ | HTR2C | P28335 | 13/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8828540 | 0.88 | HTR2A (0.49) | HTR2AHTR2BHTR2CL3MBTL1HTR1A | |
| SCHEMBL8828159 | 0.87 | HTR2A (0.47) | HTR2AHTR2BHTR2CL3MBTL1HTR1A | |
| SCHEMBL8828324 | 0.87 | HTR2A (0.48) | HTR2AHTR2BHTR2CL3MBTL1HTR1A | |
| SCHEMBL9044808 | 0.84 | HTR2A (0.49) | HTR2AHTR2BHTR2CL3MBTL1HTR1A | |
| SCHEMBL8828397 | 0.80 | L3MBTL1 (0.60) | HTR2AHTR2BHTR2CL3MBTL1HTR1A | |
| SCHEMBL9047228 | 0.77 | TRPM8 (0.45) | HTR2AHTR2BHTR2CHTR1ASLC6A4 | |
| SCHEMBL9045792 | 0.76 | L3MBTL1 (0.53) | HTR2AHTR2BHTR2CL3MBTL1OPRM1 | |
| SCHEMBL8828277 | 0.75 | KDM4E (0.66) | L3MBTL1DRD2DRD3 | |
| SCHEMBL8828377 | 0.75 | CYP3A4 (0.50) | OPRM1 | |
| SCHEMBL8828132 | 0.75 | MAPT (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0344577-B1 | Butenoic or propenoic acid derivatives | EISAI CO LTD (JP) | 1996-10-09 | — | — | EP | claimed |
| EP-0527081-A1 | Substituted 3-piperazinylalkyl-2,3-dihydro-4H-1,3-benzoxazine-4-ones, their preparation and their therapeutical use | PIERRE FABRE MEDICAMENT (FR) | 1993-02-10 | — | — | EP | claimed |
| EP-0359627-A1 | 2,3-Dihydro-3-arylalkylaminoalkyl-4H-1,3-benzoxazin-4-one derivatives, their preparation and their use as therapeutic agents | PIERRE FABRE MEDICAMENT (FR) | 1990-03-21 | — | — | EP | claimed |
| EP-0527081-B1 | Substituted 3-piperazinylalkyl-2,3-dihydro-4H-1,3-benzoxazine-4-ones, their preparation and their therapeutical use | PF MEDICAMENT (FR) | 1996-01-03 | — | — | EP | disclosed |
| EP-0527081-A1 | Substituted 3-piperazinylalkyl-2,3-dihydro-4H-1,3-benzoxazine-4-ones, their preparation and their therapeutical use | PIERRE FABRE MEDICAMENT (FR) | 1993-02-10 | — | — | EP | disclosed |
| EP-0359627-A1 | 2,3-Dihydro-3-arylalkylaminoalkyl-4H-1,3-benzoxazin-4-one derivatives, their preparation and their use as therapeutic agents | PIERRE FABRE MEDICAMENT (FR) | 1990-03-21 | — | — | EP | disclosed |