Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | SLC16A3 | O15427 | 4/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27373805 | 0.89 | ALDH1A1 (0.46) | LMNAALDH1A1FOLH1SMN1; SMN2KDM4E | |
| SCHEMBL1131361 | 0.83 | TSHR (0.46) | LMNAALDH1A1FOLH1CYP3A4CYP2D6 | |
| SCHEMBL10420414 | 0.83 | LMNA (0.45) | LMNAALDH1A1FOLH1SMN1; SMN2KDM4E | |
| SCHEMBL9047296 | 0.83 | FOLH1 (0.61) | ALDH1A1FOLH1SLC16A3HTT | |
| SCHEMBL30664751 | 0.81 | LMNA (0.44) | LMNAALDH1A1FOLH1SMN1; SMN2KDM4E | |
| SCHEMBL298005 | 0.81 | LIPG (0.53) | LMNAALDH1A1CYP3A4HTT | |
| SCHEMBL10422004 | 0.81 | LMNA (0.44) | LMNAALDH1A1FOLH1SMN1; SMN2KDM4E | |
| SCHEMBL2534110 | 0.80 | LMNA (0.43) | LMNAALDH1A1FOLH1SMN1; SMN2KDM4E | |
| SCHEMBL11441324 | 0.80 | LIPG (0.56) | LMNAALDH1A1 | |
| SCHEMBL9131501 | 0.80 | LMNA (0.42) | LMNAALDH1A1FOLH1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1167366-A1 | AMINE DERIVATIVES | Sankyo Company, Limited (JP) | 2002-01-02 | — | — | EP | disclosed |
| EP-0690854-A1 | 1-PHENYL-IMIDAZOL-2-ONE BIPHENYLMETHYL COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1996-01-10 | — | — | EP | disclosed |
| EP-0664802-A1 | N-ARYLHETEROARYLALKYL 1-PHENYL-IMIDAZOL-2-ONE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1995-08-02 | — | — | EP | disclosed |