SCHEMBL9047627

SCHEMBL9047627

O=C1O[C@@H](CO)CN1c1cc2ccc(Br)cc2s1

nearest known ligand 0.44

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
MAOA P21397 2/20 0.44
MAOB P27338 2/20 0.44
CALML3 P27482 6/20 0.39
CYP3A4 P08684 1/20 0.35
THRB P10828 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
GRM2 Q14416 1/20 0.33
F10 P00742 2/20 0.33
CHRNA7 P36544 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9050669 0.78 MAOA (0.49) MAOAMAOBCALML3GRM2F10
SCHEMBL8801477 0.75 MAOA (0.49) MAOAMAOBCALML3CYP3A4CYP2C19
SCHEMBL16685880 0.74 MAOA (0.58) MAOAMAOBCALML3CYP3A4THRB
SCHEMBL412168 0.74 MAOA (0.58) MAOAMAOBCALML3CYP3A4THRB
SCHEMBL16686258 0.74 MAOA (0.55) MAOAMAOBCALML3CYP3A4THRB
SCHEMBL16686255 0.74 MAOA (0.55) MAOAMAOBCALML3CYP3A4THRB
SCHEMBL2897920 0.73 CALML3 (0.50) MAOAMAOBCALML3GRM2F10
SCHEMBL16685649 0.73 CALML3 (0.50) MAOAMAOBCALML3GRM2F10
SCHEMBL7081038 0.70 MAOA (0.48) MAOAMAOBCALML3CYP2C9CYP2C19
SCHEMBL15856197 0.69 MAOA (0.47) MAOAMAOBCALML3CYP3A4THRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0693491-A1 Oxazolidinones substituted by 5-membered heteroaryl group as antibacterial medicine BAYER AG (DE) 1996-01-24 EP disclosed