Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.56 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7203773 | 0.78 | MKNK1 (0.53) | MKNK1MKNK2RAB9ANPC1KMT2A | |
| SCHEMBL9045673 | 0.76 | MKNK1 (0.50) | MKNK1MKNK2RAB9ANPC1KMT2A | |
| SCHEMBL6231163 | 0.75 | RAB9A (0.79) | MKNK1MKNK2RAB9ANPC1KMT2A | |
| SCHEMBL6263733 | 0.73 | RAB9A (0.61) | MKNK1MKNK2RAB9ANPC1KMT2A | |
| SCHEMBL15425110 | 0.73 | MKNK1 (0.64) | MKNK1MKNK2RAB9ANPC1KMT2A | |
| SCHEMBL9049682 | 0.73 | MAPT (0.66) | MKNK1MKNK2RAB9ANPC1KMT2A | |
| SCHEMBL9047596 | 0.73 | MAPT (0.66) | MKNK1MKNK2RAB9ANPC1KMT2A | |
| SCHEMBL9049719 | 0.73 | GCGR (0.62) | MKNK1MKNK2RAB9ANPC1KMT2A | |
| SCHEMBL9048096 | 0.73 | KMT2A (0.64) | MKNK1MKNK2RAB9ANPC1KMT2A | |
| SCHEMBL2053641 | 0.73 | L3MBTL1 (0.47) | RAB9ANPC1KMT2AMEN1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0731796-A1 | 1,3,5-TRISUBSTITUTED PYRAZOLE COMPOUNDS FOR TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-09-18 | — | — | EP | claimed |
| WO-1995015318-A1 | 1,3,5-TRISUBSTITUTED PYRAZOLE COMPOUNDS FOR TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-06-08 | — | — | WO | claimed |