Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 3/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.42 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9046560 | 0.88 | GABRA1 (0.40) | GABRA1GABRB2TSHRTAAR1HTR1A | |
| SCHEMBL9050695 | 0.83 | GABRA1 (0.36) | GABRA1GABRB2GPR52TAAR1HTR1A | |
| SCHEMBL9044851 | 0.81 | ALDH1A1 (0.40) | GPR52ALDH1A1 | |
| SCHEMBL9046020 | 0.80 | TAAR1 (0.36) | GABRA1GABRB2TAAR1HTR1A | |
| SCHEMBL9045988 | 0.80 | GABRA1 (0.34) | GABRA1GABRB2TSHRTAAR1HTR1A | |
| SCHEMBL9045061 | 0.79 | GABRA1 (0.45) | GABRA1GABRB2TSHRTAAR1HTR1A | |
| SCHEMBL19289793 | 0.78 | GABRA1 (0.52) | GABRA1GABRB2TSHRTAAR1HTR1A | |
| SCHEMBL9044815 | 0.78 | TAAR1 (0.37) | TAAR1ALDH1A1LMNA | |
| SCHEMBL9046829 | 0.78 | EED (0.40) | TAAR1ALDH1A1 | |
| SCHEMBL9048354 | 0.78 | GABRA1 (0.36) | GABRA1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690854-A1 | 1-PHENYL-IMIDAZOL-2-ONE BIPHENYLMETHYL COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | G.D. SEARLE & CO. (US) | 1996-01-10 | — | — | EP | disclosed |