Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 9/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9047075 | 0.88 | ALOX5 (0.59) | ALOX5KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL9047820 | 0.86 | ALOX5 (0.51) | ALOX5SMN1; SMN2TDP1 | |
| SCHEMBL9047238 | 0.86 | ALOX5 (0.51) | ALOX5KDM4EALDH1A1PTGS2 | |
| SCHEMBL9045840 | 0.81 | ALOX5 (1.00) | ALOX5ALOX12PTGS1PTGS2 | |
| SCHEMBL9048427 | 0.78 | ALOX5 (0.66) | ALOX5KDM4EALDH1A1SMN1; SMN2HTR1D | |
| SCHEMBL9045831 | 0.72 | ALOX5 (0.82) | ALOX5ALDH1A1ALOX12MEN1KMT2A | |
| SCHEMBL8782626 | 0.72 | KDM4E (0.61) | ALOX5KDM4EALDH1A1SMN1; SMN2HTR1D | |
| SCHEMBL9047628 | 0.72 | ALOX5 (0.82) | ALOX5ALOX12PTGS1PTGS2TDP1 | |
| SCHEMBL9049044 | 0.72 | ALOX5 (0.82) | ALOX5 | |
| SCHEMBL8550646 | 0.71 | ALOX5 (0.52) | ALOX5ALOX12PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0540673-B1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LAB (US) | 1996-10-16 | — | — | EP | claimed |
| EP-0540673-A4 | — | — | 1994-04-27 | — | — | EP | claimed |
| EP-0540673-A1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY. | ABBOTT LAB (US) | 1993-05-12 | — | — | EP | claimed |
| WO-1992001682-A1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LABORATORIES (US) | 1992-02-06 | — | — | WO | claimed |
| EP-0540673-B1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LAB (US) | 1996-10-16 | — | — | EP | disclosed |
| US-5559144-A | LIPOXYGENASE INHIBITORS, INHIBITORS OF BIOSYNTHESIS OF LEUKOTRIENES | ABBOTT LABORATORIES (US) | 1996-09-24 | — | — | US | disclosed |
| US-5476873-A | Inhibit biosynthesis of leukotrienes | ABBOTT LABORATORIES (US) | 1995-12-19 | — | — | US | disclosed |
| EP-0540673-A4 | — | — | 1994-04-27 | — | — | EP | disclosed |
| EP-0540673-A1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY. | ABBOTT LAB (US) | 1993-05-12 | — | — | EP | disclosed |
| WO-1992001682-A1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LABORATORIES (US) | 1992-02-06 | — | — | WO | disclosed |