Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.52 |
| ▸ | HTR1A | P08908 | 3/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | HTR6 | P50406 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9047511 | 0.88 | HTR1A (0.54) | KCNH2SIGMAR1HTR1ADRD2HTR2A | |
| SCHEMBL9045178 | 0.85 | DRD3 (0.62) | KCNH2SIGMAR1HTR1ADRD2HTR2A | |
| SCHEMBL9374506 | 0.84 | KCNH2 (0.56) | KCNH2SIGMAR1HTR1ADRD2HTR2A | |
| SCHEMBL9369437 | 0.84 | KCNH2 (0.59) | KCNH2SIGMAR1HTR1ADRD2HTR2A | |
| SCHEMBL9048535 | 0.81 | HTR1A (0.65) | KCNH2HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL9049049 | 0.81 | HTR1A (0.61) | KCNH2HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL9049248 | 0.79 | DRD2 (0.71) | SIGMAR1HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL9375631 | 0.79 | HTR1A (0.59) | KCNH2HTR1ADRD2HTR2AHTR7 | |
| Hydrochloric Acid SCHEMBL9587355 | 0.79 | DRD2 (0.69) | SIGMAR1HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL9049140 | 0.78 | HTR1A (0.56) | HTR1ADRD2HTR2AHTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0527081-B1 | Substituted 3-piperazinylalkyl-2,3-dihydro-4H-1,3-benzoxazine-4-ones, their preparation and their therapeutical use | PF MEDICAMENT (FR) | 1996-01-03 | — | — | EP | claimed |
| US-5308844-A | ANTIDEPRESSANT, ANXIOLYTIC AGENT, ANALGESIC, HYPOTENSIVE AGENT | PIERRE FABRE MEDICAMENT (FR) | 1994-05-03 | — | — | US | disclosed |