Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 5/20 | 0.62 |
| ▸ | DRD2 | P14416 | 5/20 | 0.62 |
| ▸ | DRD5 | P21918 | 2/20 | 0.62 |
| ▸ | DRD1 | P21728 | 3/20 | 0.61 |
| ▸ | HTR1A | P08908 | 8/20 | 0.55 |
| ▸ | HTR2A | P28223 | 5/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.55 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.55 |
| ▸ | HTR7 | P34969 | 7/20 | 0.54 |
| ▸ | HTR6 | P50406 | 3/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9049248 | 0.94 | DRD2 (0.71) | DRD3DRD2DRD5DRD1HTR1A | |
| Hydrochloric Acid SCHEMBL9587355 | 0.93 | DRD2 (0.69) | DRD3DRD2DRD5DRD1HTR1A | |
| SCHEMBL9047785 | 0.86 | HTR2C (0.51) | DRD3DRD2DRD5DRD1HTR1A | |
| SCHEMBL9048565 | 0.85 | KCNH2 (0.53) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL9047511 | 0.85 | HTR1A (0.54) | DRD3DRD2DRD5HTR1AHTR2A | |
| SCHEMBL9369051 | 0.81 | DRD2 (0.63) | DRD3DRD2DRD5DRD1HTR1A | |
| SCHEMBL9050672 | 0.79 | HTR7 (0.55) | DRD3DRD2DRD5DRD1HTR1A | |
| SCHEMBL9048535 | 0.78 | HTR1A (0.65) | DRD3DRD2DRD5HTR1AHTR2A | |
| SCHEMBL9049049 | 0.78 | HTR1A (0.61) | DRD3DRD2DRD5HTR1AHTR2A | |
| SCHEMBL11631810 | 0.77 | DRD2 (0.72) | DRD3DRD2DRD5DRD1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0527081-B1 | Substituted 3-piperazinylalkyl-2,3-dihydro-4H-1,3-benzoxazine-4-ones, their preparation and their therapeutical use | PF MEDICAMENT (FR) | 1996-01-03 | — | — | EP | claimed |
| EP-0722446-A1 | DISTAMYCIN A ANALOGUES AS ANTITUMOUR OR ANTIVIRAL AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 1996-07-24 | — | — | EP | disclosed |
| WO-1996005196-A1 | DISTAMYCIN A ANALOGUES AS ANTITUMOUR OR ANTIVIRAL AGENTS | PHARMACIA S.P.A. (IT) | 1996-02-22 | — | — | WO | disclosed |
| US-5308844-A | ANTIDEPRESSANT, ANXIOLYTIC AGENT, ANALGESIC, HYPOTENSIVE AGENT | PIERRE FABRE MEDICAMENT (FR) | 1994-05-03 | — | — | US | disclosed |