Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 6/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.46 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | RECQL | P46063 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10986628 | 0.82 | MTNR1A (0.56) | MTNR1AMTNR1BNPC1SMN1; SMN2RAB9A | |
| SCHEMBL13222645 | 0.78 | FFAR1 (0.57) | MTNR1AMTNR1BNPC1SMN1; SMN2RAB9A | |
| SCHEMBL28145857 | 0.77 | ALDH1A1 (0.49) | MTNR1AMTNR1BNPC1SMN1; SMN2RAB9A | |
| SCHEMBL8896303 | 0.77 | ALDH1A1 (0.49) | MTNR1AMTNR1BNPC1SMN1; SMN2RAB9A | |
| SCHEMBL8896348 | 0.76 | MTNR1A (0.56) | MTNR1AMTNR1BNPC1SMN1; SMN2RAB9A | |
| SCHEMBL8342307 | 0.76 | ALDH1A1 (0.52) | MTNR1AMTNR1BNPC1SMN1; SMN2RAB9A | |
| SCHEMBL9427645 | 0.76 | ALDH1A1 (0.56) | MTNR1AMTNR1BNPC1SMN1; SMN2RAB9A | |
| SCHEMBL7367695 | 0.75 | LMNA (0.57) | NPC1SMN1; SMN2RAB9ARECQLALDH1A1 | |
| SCHEMBL5412378 | 0.75 | MTNR1A (0.45) | MTNR1AMTNR1B | |
| SCHEMBL9427635 | 0.74 | ALDH1A1 (0.54) | MTNR1AMTNR1BNPC1SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0115770-B2 | Thiazole Derivatives | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1996-06-19 | — | — | EP | disclosed |
| US-4695639-A | Thiazole derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1987-09-22 | — | — | US | disclosed |
| EP-0115770-B1 | THIAZOLE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 1987-07-22 | — | — | EP | disclosed |
| EP-0115770-A1 | Thiazole Derivatives | Takeda Chemical Industries, Ltd. (JP) | 1984-08-15 | — | — | EP | disclosed |