Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.58 |
| ▸ | DRD3 | P35462 | 4/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | CCR1 | P32246 | 2/20 | 0.54 |
| ▸ | HTR1A | P08908 | 2/20 | 0.53 |
| ▸ | DRD1 | P21728 | 2/20 | 0.53 |
| ▸ | DRD4 | P21917 | 2/20 | 0.53 |
| ▸ | DRD5 | P21918 | 2/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.53 |
| ▸ | HRH2 | P25021 | 2/20 | 0.53 |
| ▸ | HTR1D | P28221 | 2/20 | 0.53 |
| ▸ | HTR2A | P28223 | 2/20 | 0.53 |
| ▸ | HTR2C | P28335 | 2/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.53 |
| ▸ | HTR7 | P34969 | 2/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.53 |
| ▸ | HTR2B | P41595 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL904909 | 0.95 | CYP3A4 (0.57) | DRD2DRD3SIGMAR1LMNAHTR1A | |
| SCHEMBL904873 | 0.91 | DRD2 (0.54) | DRD2DRD3SIGMAR1LMNAHTR1A | |
| SCHEMBL904872 | 0.90 | CYP3A4 (0.55) | DRD2DRD3LMNAHTR1ADRD1 | |
| SCHEMBL904879 | 0.90 | CYP3A4 (0.53) | DRD2DRD3SIGMAR1LMNAHTR1A | |
| SCHEMBL904880 | 0.88 | TACR3 (0.54) | DRD2DRD3SIGMAR1LMNAHTR1A | |
| SCHEMBL904881 | 0.86 | OPRM1 (0.73) | DRD2DRD3HTR1ADRD1DRD4 | |
| SCHEMBL904936 | 0.86 | CYP2C19 (0.63) | DRD2DRD3LMNAHTR1ADRD1 | |
| SCHEMBL904929 | 0.84 | TACR3 (0.55) | DRD2DRD3LMNAHTR1ADRD1 | |
| SCHEMBL905011 | 0.84 | DRD2 (0.71) | DRD2DRD3SIGMAR1LMNADRD4 | |
| SCHEMBL904905 | 0.82 | DRD2 (0.83) | DRD2DRD3SIGMAR1LMNACCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011143444-A2 | DIPHENYLBUTYPIPERIDINE AUTOPHAGY INDUCERS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-11-17 | — | — | WO | disclosed |