Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 12/20 | 0.34 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12133606 | 0.84 | ALOX5 (0.34) | ALOX5OPRL1NPC1RAB9ABACE1 | |
| SCHEMBL9049881 | 0.74 | OPRL1 (0.49) | ALOX5OPRL1BACE1 | |
| SCHEMBL9051158 | 0.71 | F2RL3 (0.35) | ALOX5F2RL3 | |
| SCHEMBL12133618 | 0.69 | CNR2 (0.39) | OPRL1BACE1 | |
| SCHEMBL9048558 | 0.69 | BACE1 (0.36) | ALOX5BACE1 | |
| SCHEMBL25933403 | 0.68 | F2RL3 (0.44) | ALOX5F2RL3 | |
| SCHEMBL15349023 | 0.68 | F2RL3 (0.41) | ALOX5F2RL3 | |
| SCHEMBL1357154 | 0.68 | ALOX5 (0.32) | ALOX5OPRL1 | |
| SCHEMBL19508120 | 0.66 | ALOX15 (0.36) | OPRL1BACE1 | |
| SCHEMBL9126495 | 0.66 | ALOX5 (0.33) | ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0555068-B1 | Oxime derivatives as 5-lipoxygenase inhibitors | ZENECA LTD (GB) | 1996-04-10 | — | — | EP | disclosed |
| US-5482966-A | LIPOXYGENASE ENZYME INHIBITORS AS ANTIINFLAMMATORY AGENTS | ZENECA LIMITED (GB) | 1996-01-09 | — | — | US | disclosed |
| US-5332757-A | Enzyme inhibitors | ZENECA LIMITED (GB) | 1994-07-26 | — | — | US | disclosed |
| EP-0555068-A1 | Oxime derivatives as 5-lipoxygenase inhibitors | ZENECA LIMITED (GB) | 1993-08-11 | — | — | EP | disclosed |