Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 5/20 | 0.49 |
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.48 |
| ▸ | HTR1D | P28221 | 8/20 | 0.49 |
| ▸ | HTR1A | P08908 | 5/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 5/20 | 0.47 |
| ▸ | HTR7 | P34969 | 4/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | HTR6 | P50406 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 5/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7463598 | 0.95 | OPRM1 (0.52) | HTR1DSLC6A4HTR1AOPRM1OPRK1 | |
| Oxalic Acid SCHEMBL9048457 | 0.90 | HTR1D (0.41) | HTR1DHTR1AOPRM1OPRK1OPRL1 | |
| Oxalic Acid SCHEMBL9046836 | 0.89 | SLC6A4 (0.51) | SLC6A4HTR1ADRD2HTR7HTR2A | |
| Oxalic Acid SCHEMBL9046929 | 0.87 | SLC6A4 (0.54) | HTR1DSLC6A4HTR1AOPRM1OPRK1 | |
| SCHEMBL7459131 | 0.86 | CYP1A2 (0.56) | HTR1DSLC6A4HTR1AOPRM1OPRK1 | |
| Oxalic Acid SCHEMBL9046848 | 0.85 | HTR1A (0.51) | HTR1DSLC6A4HTR1AOPRM1OPRK1 | |
| Oxalic Acid SCHEMBL7864877 | 0.85 | OPRM1 (0.44) | SLC6A4OPRM1OPRK1OPRL1DRD2 | |
| SCHEMBL8111835 | 0.85 | OPRM1 (0.57) | HTR1DSLC6A4HTR1AOPRM1OPRK1 | |
| SCHEMBL7460288 | 0.84 | OPRM1 (0.56) | HTR1DSLC6A4HTR1AOPRM1OPRK1 | |
| Oxalic Acid SCHEMBL9044395 | 0.84 | OPRM1 (0.54) | HTR1DSLC6A4HTR1AOPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0708102-A1 | 5-HT1F agonists for the treatment of migraine | ELI LILLY AND COMPANY (US) | 1996-04-24 | — | — | EP | disclosed |