Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | MAP3K14 | Q99558 | 3/20 | 0.36 |
| ▸ | AHR | P35869 | 3/20 | 0.35 |
| ▸ | BACE1 | P56817 | 3/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19889341 | 0.79 | LMNA (0.47) | LMNAMAPTHTTBLMMAP3K14 | |
| SCHEMBL4847627 | 0.77 | LMNA (0.46) | LMNAMAPTHTTBLMMAP3K14 | |
| SCHEMBL30250112 | 0.77 | LMNA (0.46) | LMNAMAPTHTTBLMMAP3K14 | |
| SCHEMBL19889348 | 0.77 | LMNA (0.46) | LMNAMAPTHTTBLMMAP3K14 | |
| SCHEMBL17495177 | 0.77 | BACE1 (0.45) | LMNAMAPTHTTBLMAHR | |
| SCHEMBL9050393 | 0.76 | ALDH1A1 (0.45) | MAPTMAP3K14 | |
| SCHEMBL9049281 | 0.76 | MAP3K14 (0.38) | MAP3K14SMN1; SMN2 | |
| SCHEMBL23362642 | 0.75 | MAP3K14 (0.43) | LMNAMAPTHTTBLMMAP3K14 | |
| SCHEMBL23362552 | 0.75 | MAPT (0.43) | LMNAMAPTHTTBLMMAP3K14 | |
| SCHEMBL4817625 | 0.74 | KDM1A (0.40) | AHRBACE1PKMADRA2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024254599-A1 | HPGD INHIBITORS AND USES THEREOF | NIMBUS DISCOVERY, INC. (US) | 2024-12-12 | — | — | WO | disclosed |
| EP-0555068-B1 | Oxime derivatives as 5-lipoxygenase inhibitors | ZENECA LTD (GB) | 1996-04-10 | — | — | EP | disclosed |
| US-5482966-A | LIPOXYGENASE ENZYME INHIBITORS AS ANTIINFLAMMATORY AGENTS | ZENECA LIMITED (GB) | 1996-01-09 | — | — | US | disclosed |
| US-5332757-A | Enzyme inhibitors | ZENECA LIMITED (GB) | 1994-07-26 | — | — | US | disclosed |
| EP-0581464-A1 | Ester derivatives and pharmaceutical compositions containing them | ZENECA LIMITED (GB) | 1994-02-02 | — | — | EP | disclosed |
| EP-0555068-A1 | Oxime derivatives as 5-lipoxygenase inhibitors | ZENECA LIMITED (GB) | 1993-08-11 | — | — | EP | disclosed |