Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 3/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 4/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.30 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4815280 | 0.76 | ESR2 (0.37) | CYP26A1CYP26B1 | |
| SCHEMBL9049308 | 0.76 | LMNA (0.44) | MAP3K14SMN1; SMN2 | |
| SCHEMBL4810769 | 0.74 | PDK2 (0.33) | — | |
| SCHEMBL31189879 | 0.73 | KDM4E (0.41) | KDM4ESMN1; SMN2CYP26A1CYP26B1 | |
| SCHEMBL9050393 | 0.72 | ALDH1A1 (0.45) | MAP3K14KDM4E | |
| SCHEMBL11949156 | 0.72 | PARP1 (0.40) | MAP3K14AKR1B1CYP26A1CYP26B1 | |
| SCHEMBL20225729 | 0.70 | PDCD1 (0.57) | PDCD1CD274CYP3A4CYP2D6 | |
| SCHEMBL695934 | 0.70 | PDCD1 (0.57) | PDCD1CD274CYP3A4CYP2D6 | |
| SCHEMBL2246604 | 0.70 | CYP26A1 (0.51) | MAP3K14PDCD1CD274AKR1B1CYP26A1 | |
| SCHEMBL31189901 | 0.70 | RARB (0.49) | KDM4ESMN1; SMN2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0555068-B1 | Oxime derivatives as 5-lipoxygenase inhibitors | ZENECA LTD (GB) | 1996-04-10 | — | — | EP | disclosed |
| US-5482966-A | LIPOXYGENASE ENZYME INHIBITORS AS ANTIINFLAMMATORY AGENTS | ZENECA LIMITED (GB) | 1996-01-09 | — | — | US | disclosed |
| US-5332757-A | Enzyme inhibitors | ZENECA LIMITED (GB) | 1994-07-26 | — | — | US | disclosed |
| EP-0581464-A1 | Ester derivatives and pharmaceutical compositions containing them | ZENECA LIMITED (GB) | 1994-02-02 | — | — | EP | disclosed |
| EP-0555068-A1 | Oxime derivatives as 5-lipoxygenase inhibitors | ZENECA LIMITED (GB) | 1993-08-11 | — | — | EP | disclosed |