Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | PRCP | P42785 | 2/20 | 0.39 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.38 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2908444 | 0.79 | PDE10A (0.45) | KDM4EALDH1A1RPS6KB1PDE10AGSK3B | |
| SCHEMBL2910280 | 0.79 | PDE10A (0.45) | KDM4EALDH1A1RPS6KB1PDE10AGSK3B | |
| SCHEMBL90572 | 0.79 | PDE10A (0.45) | KDM4EALDH1A1RPS6KB1PDE10AGSK3B | |
| SCHEMBL2708307 | 0.78 | ADRB1 (0.50) | KDM4EALDH1A1RPS6KB1PDE10AGSK3B | |
| SCHEMBL10388908 | 0.78 | KDM4E (0.44) | KDM4EALDH1A1RPS6KB1PDE10AGSK3B | |
| Hydrochloric Acid SCHEMBL10626673 | 0.78 | GSK3B (0.45) | KDM4EALDH1A1RPS6KB1PDE10AGSK3B | |
| Hydrochloric Acid SCHEMBL27510131 | 0.78 | GSK3B (0.45) | KDM4EALDH1A1RPS6KB1PDE10AGSK3B | |
| SCHEMBL3277741 | 0.78 | SIGMAR1 (0.54) | ALDH1A1SIGMAR1KMT2AMEN1CYP2C19 | |
| SCHEMBL3272922 | 0.78 | SIGMAR1 (0.54) | ALDH1A1SIGMAR1KMT2AMEN1CYP2C19 | |
| SCHEMBL3272931 | 0.78 | SIGMAR1 (0.54) | ALDH1A1SIGMAR1KMT2AMEN1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0527081-B1 | Substituted 3-piperazinylalkyl-2,3-dihydro-4H-1,3-benzoxazine-4-ones, their preparation and their therapeutical use | PF MEDICAMENT (FR) | 1996-01-03 | — | — | EP | disclosed |
| EP-0294307-B1 | 3-Arylcarbamoyl-5-aminomethyl-oxazolidines, and their salts with pharmaceutically acceptable acids | CORTIAL (FR) | 1994-06-22 | — | — | EP | disclosed |
| EP-0527081-A1 | Substituted 3-piperazinylalkyl-2,3-dihydro-4H-1,3-benzoxazine-4-ones, their preparation and their therapeutical use | PIERRE FABRE MEDICAMENT (FR) | 1993-02-10 | — | — | EP | disclosed |
| EP-0294307-A1 | 3-Arylcarbamoyl-5-aminomethyl-oxazolidines, and their salts with pharmaceutically acceptable acids | CORTIAL S.A. (FR) | 1988-12-07 | — | — | EP | disclosed |
| EP-0199641-B1 | TRIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ADIR ET COMPAGNIE (FR) | 1988-09-21 | — | — | EP | disclosed |
| EP-0199641-A1 | Triazole derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1986-10-29 | — | — | EP | disclosed |