Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | PRCP | P42785 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2908444 | 1.00 | PDE10A (0.45) | PDE10AGSK3BKDM4EALDH1A1RPS6KB1 | |
| SCHEMBL2910280 | 1.00 | PDE10A (0.45) | PDE10AGSK3BKDM4EALDH1A1RPS6KB1 | |
| Hydrochloric Acid SCHEMBL10626673 | 0.98 | GSK3B (0.45) | PDE10AGSK3BKDM4EALDH1A1RPS6KB1 | |
| Hydrochloric Acid SCHEMBL27510131 | 0.98 | GSK3B (0.45) | PDE10AGSK3BKDM4EALDH1A1RPS6KB1 | |
| Oxalic Acid SCHEMBL4354000 | 0.92 | RPS6KB1 (0.45) | PDE10AGSK3BRPS6KB1SLC6A2SLC6A3 | |
| Oxalic Acid SCHEMBL4354003 | 0.92 | RPS6KB1 (0.45) | PDE10AGSK3BRPS6KB1SLC6A2SLC6A3 | |
| SCHEMBL7409899 | 0.89 | PDE10A (0.41) | PDE10AGSK3BSLC6A2SLC6A3ADRA1A | |
| Diethylamine SCHEMBL28752379 | 0.88 | GSK3B (0.40) | PDE10AGSK3BRPS6KB1SLC6A2SLC6A3 | |
| SCHEMBL27765904 | 0.84 | SLC6A2 (0.46) | PDE10AGSK3BRPS6KB1SLC6A2SLC6A3 | |
| SCHEMBL2913625 | 0.84 | SLC6A2 (0.40) | PDE10AGSK3BKDM4EALDH1A1RPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 387 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118652237-A | Preparation method of environment-friendly and safe 1- (3-cyanopyridine-2) -2-phenyl-4-methylpiperazine | 兰西哈三联制药有限公司 | 2024-09-17 | — | — | CN | claimed |
| CN-108299387-B | Method for preparing mirtazapine impurity K | 心邀（深圳）生物科技有限公司 | 2020-11-17 | — | — | CN | claimed |
| US-10253006-B2 | Assay for the detection of the phenylpiperazine family | RANDOX LABORATORIES LIMITED (GB) | 2019-04-09 | — | — | US | claimed |
| CN-108299387-A | A method of preparing Mirtazapine impurity K | 心邀（深圳）生物科技有限公司 | 2018-07-20 | — | — | CN | claimed |
| CN-107266447-A | A kind of preparation method of Mirtazapine | 江西永通科技股份有限公司 | 2017-10-20 | — | — | CN | claimed |
| US-20160229824-A1 | ASSAY FOR THE DETECTION OF THE PHENYLPIPERAZINE FAMILY | NORTHERN BANK LIMITED (IE) | 2016-08-11 | — | — | US | claimed |
| CN-103588715-A | Synthetic method for 1-methyl-3-phenylpiperazine | TAICANG YUNTONG BIOCHEMICAL ENGINEERING CO LTD | 2014-02-19 | — | — | CN | claimed |
| CN-102432594-B | Method for preparing 1-(3-hydroxymethylpyridine-2-yl)-2-phenyl-4-methyl piperazine serving as medicinal intermediate | SHANDONG LUYAO PHARMACEUTICAL CO LTD | 2013-09-11 | — | — | CN | claimed |
| CN-102649779-A | Synthesis method for medicine intermediate 1-methyl-3-phenylpiperazine | SHANDONG LUYAO PHARMACEUTICAL CO LTD | 2012-08-29 | — | — | CN | claimed |
| EP-2038260-B1 | STEREOSELECTIVE SYNTHESIS OF (S)-1-METHYL-3-PHENYLPIPERAZINE | ORGANON NV (NL) | 2010-09-01 | — | — | EP | claimed |
| WO-2004106309-A1 | A PROCESS FOR PREPARING 1-METHYL-3-PHENYLPIPERAZINE | AUROBINDO PHARMA LTD (IN) | 2004-12-09 | — | — | WO | claimed |
| US-20040242879-A1 | Process for preparing 1-methyl-3-phenylpiperazine using a novel intermediate | AUROBINTO PHARMA LTD (IN) | 2004-12-02 | — | — | US | claimed |
| US-20040236107-A1 | Intermediate compounds for the preparation of mirtazapine and the production methods thereof | MEDICHEM, S.A. (ES) | 2004-11-25 | — | — | US | claimed |
| EP-1426356-A1 | INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF MIRTAZAPINE AND THE PRODUCTION METHODS THEREOF | Medichem S.A. (ES) | 2004-06-09 | — | — | EP | claimed |
| US-6603003-B2 | Reacting ester with substituted or unsubstituted ethylenediamine to give 3,4-dehydropiperazine-2-one and reacting 3,4-dehydropiperazine-2-one with reducing agent to yield piperazine derivative | SUN PHARMACEUTICAL INDUSTRIES LTD (IN) | 2003-08-05 | — | — | US | claimed |
| US-6495685-B1 | COMPRISING REACTING 1-METHYL-3-PHENYLPIPERAZINE WITH 2-CHLORO-3-CYANOPYRIDINE IN AN APROTIC POLAR ORGANIC SOLVENT IN THE PRESENCE OF A BASE AND AN ALKALI METAL HALIDE. THE PIPERAZINE DERIVATIVE AND ITS OXALATE ARE COMPOUNDS AS | SUMIKA FINE CHEMICALS CO., LTD. (JP) | 2002-12-17 | — | — | US | claimed |
| WO-2002090339-A1 | A PROCESS FOR PREPARING 1-METHYL-3-PHENYL-PIPERAZINE | NEULAND LABORATORIES LIMITED (IN) | 2002-11-14 | — | — | WO | claimed |
| US-20020095038-A1 | Novel method for the preparation of piperazine and its derivatives | SUN PHARMACEUTICAL INDUSTRIES LTD (IN) | 2002-07-18 | — | — | US | claimed |
| WO-2002038552-A1 | A NOVEL METHOD FOR THE PREPARATION OF PIPERAZINE AND ITS DERIVATIVES | SUN PHARMACEUTICAL INDUSTRIES LTD. (IN) | 2002-05-16 | — | — | WO | claimed |
| EP-1136470-A1 | PROCESS FOR THE PREPARATION OF A PIPERAZINE DERIVATIVE | SUMIKA FINE CHEMICALS Co., Ltd. (JP) | 2001-09-26 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040236107-A1 | Intermediate compounds for the preparation of mirtazapine and the production methods thereof | IMPDH1, MRM1, IMPDH2 | PDE10A 1006/4885GSK3B 2215/4885KDM4E 2908/4885 |
| US-20040242879-A1 | Process for preparing 1-methyl-3-phenylpiperazine using a novel intermediate | CYP4Z1, HTR5A, CYP3A5 | PDE10A 1913/4885GSK3B 1605/4885KDM4E 121/4885 |
| US-20020095038-A1 | Novel method for the preparation of piperazine and its derivatives | DHPS, DRD4, CYP2E1 | PDE10A 3204/4885GSK3B 4694/4885KDM4E 525/4885 |
| US-10253006-B2 | Assay for the detection of the phenylpiperazine family | METAP2, DCPS, NPEPPS | PDE10A 1702/4885GSK3B 4872/4885KDM4E 2686/4885 |
| US-20160229824-A1 | ASSAY FOR THE DETECTION OF THE PHENYLPIPERAZINE FAMILY | METAP2, DCPS, NPEPPS | PDE10A 1702/4885GSK3B 4872/4885KDM4E 2686/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.