Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 5/20 | 0.39 |
| ▸ | MAOA | P21397 | 4/20 | 0.39 |
| ▸ | APP | P05067 | 6/20 | 0.39 |
| ▸ | TOP1 | P11387 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8440875 | 0.80 | MAOA (0.55) | MAOBMAOAAPPTOP1 | |
| SCHEMBL9077007 | 0.74 | ERBB2 (0.41) | MAOBMAOAIDO1 | |
| SCHEMBL9076984 | 0.72 | ACACB (0.39) | MAOBMAOA | |
| SCHEMBL21246500 | 0.69 | APP (0.42) | APPIDO1 | |
| SCHEMBL314468 | 0.68 | APP (0.63) | MAOBMAOAAPPNR4A2 | |
| Formaldehyde SCHEMBL27783224 | 0.68 | NR4A2 (0.61) | MAOBMAOAAPPNR4A2 | |
| SCHEMBL21177828 | 0.67 | APP (0.43) | APPIDO1 | |
| SCHEMBL22345190 | 0.67 | APP (0.43) | MAOBAPPIDO1 | |
| SCHEMBL1079030 | 0.67 | ALDH1A1 (0.46) | MAOBMAOA | |
| SCHEMBL10458635 | 0.66 | KCNH2 (0.44) | APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0540673-B1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LAB (US) | 1996-10-16 | — | — | EP | disclosed |
| US-5559144-A | LIPOXYGENASE INHIBITORS, INHIBITORS OF BIOSYNTHESIS OF LEUKOTRIENES | ABBOTT LABORATORIES (US) | 1996-09-24 | — | — | US | disclosed |
| US-5476873-A | Inhibit biosynthesis of leukotrienes | ABBOTT LABORATORIES (US) | 1995-12-19 | — | — | US | disclosed |
| EP-0540673-A4 | — | — | 1994-04-27 | — | — | EP | disclosed |
| EP-0540673-A1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY. | ABBOTT LAB (US) | 1993-05-12 | — | — | EP | disclosed |
| WO-1992001682-A1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LABORATORIES (US) | 1992-02-06 | — | — | WO | disclosed |