Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 3/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9051385 | 0.95 | HSD11B1 (0.39) | CHRM2HSD11B1CHRM4CHRM5CHRM1 | |
| Oxalic Acid SCHEMBL9050512 | 0.92 | HSD11B1 (0.41) | CHRM2HSD11B1CHRM4CHRM5CHRM1 | |
| SCHEMBL9049262 | 0.91 | CHRM2 (0.48) | CHRM2HSD11B1 | |
| Oxalic Acid SCHEMBL8790622 | 0.86 | HSD11B1 (0.41) | CHRM2HSD11B1CHRM4CHRM5CHRM1 | |
| SCHEMBL9049643 | 0.81 | HSD11B1 (0.46) | CHRM2HSD11B1 | |
| Oxalic Acid SCHEMBL9702679 | 0.75 | CHRM2 (0.31) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL8790855 | 0.75 | HSD11B1 (0.46) | CHRM2HSD11B1 | |
| Oxalic Acid SCHEMBL9879691 | 0.75 | — | — | |
| Oxalic Acid SCHEMBL9702508 | 0.75 | PDK2 (0.38) | — | |
| Oxalic Acid SCHEMBL9702692 | 0.72 | SLC6A2 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0287356-B1 | Bridgehead substituted azabicyclic derivatives | BEECHAM GROUP PLC (GB) | 1996-01-24 | — | — | EP | disclosed |
| US-5132316-A | Cognition activators | BEECHAM GROUP P.L.C. (GB) | 1992-07-21 | — | — | US | disclosed |
| US-4971975-A | TREATMENT OF DEMENTIA; AZABICYCLOOCTANE COMPOUNDS | BEECHAM GROUP PLC (GB) | 1990-11-20 | — | — | US | disclosed |
| EP-0287356-A2 | Bridgehead substituted azabicyclic derivatives | BEECHAM GROUP PLC (GB) | 1988-10-19 | — | — | EP | disclosed |