Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.30 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.30 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.30 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.30 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.30 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.30 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9703375 | 0.94 | PDK2 (0.35) | PDK2SLC10A1PSEN1PSEN2APH1B | |
| SCHEMBL9049720 | 0.91 | PDK2 (0.34) | PDK2PSEN1PSEN2APH1BNCSTN | |
| Oxalic Acid SCHEMBL8790533 | 0.85 | PDK2 (0.36) | PDK2PSEN1PSEN2APH1BNCSTN | |
| Oxalic Acid SCHEMBL9702692 | 0.77 | SLC6A2 (0.30) | — | |
| Oxalic Acid SCHEMBL9050722 | 0.75 | CHRM2 (0.42) | — | |
| SCHEMBL8790975 | 0.74 | PDK2 (0.33) | PDK2PSEN1PSEN2APH1BNCSTN | |
| Oxalic Acid SCHEMBL9702679 | 0.74 | CHRM2 (0.31) | — | |
| Oxalic Acid SCHEMBL9051385 | 0.71 | HSD11B1 (0.39) | — | |
| Oxalic Acid SCHEMBL9051431 | 0.70 | ALDH1A1 (0.31) | — | |
| Oxalic Acid SCHEMBL9702330 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5132316-A | Cognition activators | BEECHAM GROUP P.L.C. (GB) | 1992-07-21 | — | — | US | disclosed |
| US-4971975-A | TREATMENT OF DEMENTIA; AZABICYCLOOCTANE COMPOUNDS | BEECHAM GROUP PLC (GB) | 1990-11-20 | — | — | US | disclosed |
| EP-0287356-A2 | Bridgehead substituted azabicyclic derivatives | BEECHAM GROUP PLC (GB) | 1988-10-19 | — | — | EP | disclosed |