Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 5/20 | 0.41 |
| ▸ | GART | P22102 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.38 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9052458 | 0.95 | GART (0.44) | RARBGARTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9051507 | 0.88 | CYP4A11 (0.46) | SMN1; SMN2 | |
| SCHEMBL9050614 | 0.82 | TP53 (0.44) | GART | |
| SCHEMBL9263780 | 0.81 | GART (0.67) | GART | |
| SCHEMBL9049069 | 0.79 | ADORA1 (0.39) | RARBGARTNPC1NFKB1RAB9A | |
| SCHEMBL9535793 | 0.78 | ALDH1A1 (0.40) | RARBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9535789 | 0.78 | ALDH1A1 (0.40) | RARBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9535831 | 0.77 | GART (0.72) | GART | |
| SCHEMBL9446029 | 0.76 | DHFR (0.53) | GART | |
| SCHEMBL9446027 | 0.76 | DHFR (0.53) | GART |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0314280-B1 | Process for the preparation of fused pyridine compounds | UNIV PRINCETON (US) | 1996-02-21 | — | — | EP | disclosed |
| US-5473071-A | Process for the preparation of fused pyridine compounds | TRUSTEES OF PRINCETON UNIVERSITY (US) | 1995-12-05 | — | — | US | disclosed |
| EP-0340905-B1 | Fused pyrimidines, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1993-12-08 | — | — | EP | disclosed |
| US-5223620-A | For antitumor agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-06-29 | — | — | US | disclosed |
| US-4946846-A | ANTITUMOR AGENTS; NONTOXIC | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1990-08-07 | — | — | US | disclosed |
| US-4895946-A | Process for the preparation of fused pyridine compounds | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1990-01-23 | — | — | US | disclosed |
| EP-0314280-A2 | Process for the preparation of fused pyridine compounds | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-05-03 | — | — | EP | disclosed |