SCHEMBL9050871

SCHEMBL9050871

O=C(CCCN1CCC(O)(CCCc2ccccc2)CC1)c1ccc(F)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 9/20 0.67
SIGMAR1 Q99720 3/20 0.57
SLC18A3 Q16572 2/20 0.57
CYP1A2 P05177 2/20 0.56
CYP3A4 P08684 2/20 0.56
HTR1A P08908 2/20 0.56
ADRA2A P08913 2/20 0.56
CYP2D6 P10635 2/20 0.56
CHRM1 P11229 2/20 0.56
ADRA2B P18089 2/20 0.56
ADRA2C P18825 2/20 0.56
CHRM3 P20309 2/20 0.56
SLC6A2 P23975 2/20 0.56
HTR2A P28223 2/20 0.56
SLC6A4 P31645 2/20 0.56
ADRA1A P35348 2/20 0.56
HRH1 P35367 2/20 0.56
OPRM1 P35372 2/20 0.56
DRD3 P35462 2/20 0.56
HTR2B P41595 2/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL11553970 0.94 DRD2 (0.67) DRD2SIGMAR1SLC18A3TSHRHTR7
SCHEMBL9052152 0.92 DRD2 (0.64) DRD2SIGMAR1HTR1AHTR2ASLC6A4
SCHEMBL9052603 0.88 DRD2 (0.71) DRD2SIGMAR1SLC18A3CYP1A2CYP3A4
SCHEMBL11834858 0.84 TSHR (0.67) DRD2SIGMAR1CYP1A2CYP3A4HTR1A
Hydrochloric Acid SCHEMBL11829536 0.83 TSHR (0.70) DRD2SIGMAR1CYP1A2CYP3A4HTR1A
SCHEMBL8986042 0.81 DRD2 (1.00) DRD2SIGMAR1CYP1A2CYP3A4HTR1A
SCHEMBL9053049 0.80 DRD2 (0.67) DRD2SIGMAR1SLC18A3HTR1AADRA2A
SCHEMBL11743201 0.79 DRD2 (0.80) DRD2SIGMAR1SLC18A3CYP1A2CYP3A4
SCHEMBL9051860 0.79 DRD2 (0.67) DRD2CYP1A2CYP3A4HTR1AADRA2A
SCHEMBL11834324 0.79 TSHR (0.67) DRD2SIGMAR1CYP1A2CYP3A4HTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1996002250-A1 HALOPERIDOL ANALOGS AND THE USE THEREOF ACEA PHARMACEUTICALS INC. (US) 1996-02-01 WO disclosed