⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1400093 | 0.76 | LIPE (0.31) | — | |
| SCHEMBL15918966 | 0.70 | — | — | |
| SCHEMBL1400145 | 0.70 | KDM4E (0.34) | — | |
| SCHEMBL12019536 | 0.67 | ALDH2 (0.44) | — | |
| SCHEMBL10044026 | 0.67 | ATAD2 (0.36) | — | |
| SCHEMBL2908849 | 0.65 | — | — | |
| SCHEMBL1399975 | 0.62 | CA1 (0.39) | — | |
| SCHEMBL278526 | 0.60 | — | — | |
| SCHEMBL10049703 | 0.59 | KDM4E (0.32) | — | |
| SCHEMBL13865236 | 0.59 | CASP3 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023009612-A1 | ACORAMIDIS (3-(3-(3,5-DIMETHYL-1H-PYRAZOL-4-YL)PROPOXY)-4-FLUOROBENZOIC ACID) DERIVATIVES FOR STABILIZING TRANSTHYRETIN (TTS) AND INHIBITING TTS MISFOLDING FOR THE TREATMENT OF E.G. PERIPHERAL TTR AMYLOIDOSIS | PROTEGO BIOPHARMA, INC. (US) | 2023-02-02 | — | — | WO | disclosed |
| WO-2018031680-A1 | NOVEL COMPOUNDS, USES AND METHODS FOR THEIR PREPARATION | FRONTHERA U.S. PHARMACEUTICALS LLC (US) | 2018-02-15 | — | — | WO | disclosed |
| US-9382481-B2 | Polarizing film, display device and production process thereof | FUJIFILM CORPORATION (JP) | 2016-07-05 | — | — | US | disclosed |
| US-8975235-B2 | Lysophosphatidic acid receptor antagonists | INTERMUNE, INC. (US) | 2015-03-10 | — | — | US | disclosed |
| WO-2014164533-A1 | METHODS OF STEREOSELECTIVE SYNTHESIS OF SUBSTITUTED NUCLEOSIDE ANALOGS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-10-09 | — | — | WO | disclosed |
| US-20140213538-A1 | LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | INTERMUNE, INC. | 2014-07-31 | — | — | US | disclosed |
| WO-2014113485-A1 | LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | INTERMUNE, INC. (US) | 2014-07-24 | — | — | WO | disclosed |
| US-20140200215-A1 | LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | INTERMUNE, INC. | 2014-07-17 | — | — | US | disclosed |
| US-20130120676-A1 | STEREO IMAGE PRINT AND METHOD OF PRODUCING THE SAME | FUJIFILM CORPORATION (JP) | 2013-05-16 | — | — | US | disclosed |
| US-20130072449-A1 | LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | INTERMUNE, INC. (US) | 2013-03-21 | — | — | US | disclosed |
| US-20130070899-A1 | POLARIZING FILM, DISPLAY DEVICE AND PRODUCTION PROCESS THEREOF | FUJIFILM CORPORATION (JP) | 2013-03-21 | — | — | US | disclosed |
| US-20120270071-A1 | CHROMENE COMPOUND | TOKUYAMA CORPORATION (JP) | 2012-10-25 | — | — | US | disclosed |
| US-20120270071-A1 | CHROMENE COMPOUND | TOKUYAMA CORPORATION (JP) | 2012-10-25 | — | — | US | disclosed |
| WO-2012043505-A1 | NOVEL PIPERIDINE DERIVATIVE AND PHARMACEUTICAL CONTAINING SAME | 興和株式会社 (JP) | 2012-04-05 | — | — | WO | disclosed |
| US-7998950-B2 | Antiviral compounds | GILEAD SCIENCES, INC. (US) | 2011-08-16 | — | — | US | disclosed |
| US-7998950-B2 | Antiviral compounds | GILEAD SCIENCES, INC. (US) | 2011-08-16 | — | — | US | disclosed |
| US-20100022508-A1 | ANTIVIRAL COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2010-01-28 | — | — | US | disclosed |
| US-20100022508-A1 | ANTIVIRAL COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2010-01-28 | — | — | US | disclosed |