Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HTR1B | P28222 | 2/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | CRHR1 | P34998 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL516226 | 0.89 | SIGMAR1 (0.48) | SIGMAR1ALDH1A1KMT2AHTR1BHTR1D | |
| SCHEMBL7772408 | 0.86 | SIGMAR1 (0.53) | SIGMAR1ALDH1A1KMT2AHTR1BHTR1D | |
| Hydrochloric Acid SCHEMBL25414408 | 0.79 | CRHR1 (0.41) | SIGMAR1ALDH1A1KMT2AHTR1BHTR1D | |
| SCHEMBL29862254 | 0.79 | HTR1B (0.50) | SIGMAR1ALDH1A1KMT2AHTR1BHTR1D | |
| SCHEMBL30301305 | 0.79 | HTR1B (0.50) | SIGMAR1ALDH1A1KMT2AHTR1BHTR1D | |
| SCHEMBL1509321 | 0.79 | HTR1B (0.50) | SIGMAR1ALDH1A1KMT2AHTR1BHTR1D | |
| SCHEMBL29657743 | 0.77 | SIGMAR1 (0.54) | SIGMAR1ALDH1A1KMT2AL3MBTL1CYP1A2 | |
| SCHEMBL517207 | 0.77 | SIGMAR1 (0.54) | SIGMAR1ALDH1A1KMT2AL3MBTL1CYP1A2 | |
| SCHEMBL28024667 | 0.77 | HTR1B (0.45) | SIGMAR1ALDH1A1KMT2AHTR1BHTR1D | |
| SCHEMBL9313557 | 0.77 | SIGMAR1 (0.52) | SIGMAR1ALDH1A1KMT2AHTR1BHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0540673-B1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LAB (US) | 1996-10-16 | — | — | EP | disclosed |
| US-5559144-A | LIPOXYGENASE INHIBITORS, INHIBITORS OF BIOSYNTHESIS OF LEUKOTRIENES | ABBOTT LABORATORIES (US) | 1996-09-24 | — | — | US | disclosed |
| US-5476873-A | Inhibit biosynthesis of leukotrienes | ABBOTT LABORATORIES (US) | 1995-12-19 | — | — | US | disclosed |
| EP-0540673-A4 | — | — | 1994-04-27 | — | — | EP | disclosed |
| US-5250565-A | Must incorporate a metabolically cleavable leaving group; pro-drugs; administering to mammals | ABBOTT LABORATORIES (US) | 1993-10-05 | — | — | US | disclosed |
| EP-0540673-A1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY. | ABBOTT LAB (US) | 1993-05-12 | — | — | EP | disclosed |
| WO-1992001682-A1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LABORATORIES (US) | 1992-02-06 | — | — | WO | disclosed |
| EP-0416609-A2 | Benzo[b]thiophene-containing lipoxygenase-inhibiting compounds | ABBOTT LABORATORIES (US) | 1991-03-13 | — | — | EP | disclosed |