⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22192813 | 0.87 | — | — | |
| SCHEMBL7945735 | 0.72 | — | — | |
| SCHEMBL145601 | 0.67 | KMT2A (0.35) | — | |
| SCHEMBL11205274 | 0.66 | ALDH1A1 (0.31) | — | |
| SCHEMBL14714137 | 0.66 | L3MBTL1 (0.37) | — | |
| SCHEMBL31439229 | 0.65 | KMT2A (0.33) | — | |
| SCHEMBL10782446 | 0.65 | — | — | |
| SCHEMBL16480080 | 0.63 | CRBN (0.32) | — | |
| SCHEMBL472573 | 0.63 | GSK3A (0.42) | — | |
| SCHEMBL18863391 | 0.63 | GSK3A (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160194323-A1 | HISTONE DEMETHYLASE INHIBITORS | CELGENE QUANTICEL RESEARCH, INC. | 2016-07-07 | — | — | US | disclosed |
| US-20160083379-A1 | HISTONE DEMETHYLASE INHIBITORS | CELGENE QUANTICEL RESEARCH, INC. | 2016-03-24 | — | — | US | disclosed |
| WO-2012043505-A1 | NOVEL PIPERIDINE DERIVATIVE AND PHARMACEUTICAL CONTAINING SAME | 興和株式会社 (JP) | 2012-04-05 | — | — | WO | disclosed |
| US-7442804-B2 | Process for the preparation of furopyrroles | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 2008-10-28 | — | — | US | disclosed |
| US-7326793-B2 | From a pyrrolidinone compound; coloring high molecular weight material | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 2008-02-05 | — | — | US | disclosed |
| US-20070100135-A1 | Process for the preparation of furopyrroles | CIBA SPECIALTY CHEMICALS CORPORATION | 2007-05-03 | — | — | US | disclosed |