Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 0.45 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.39 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.46 |
| ▸ | BLM | P54132 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 3/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.39 |
| ▸ | HTR3B | O95264 | 2/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.39 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | SPR | P35270 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9051571 | 0.92 | HTR3A (0.48) | NPSR1BLMMAPTSLC6A4HTR3A | |
| Fumaric Acid SCHEMBL9052105 | 0.87 | HTR3A (0.49) | SLC6A4HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL9051560 | 0.83 | HTR3A (0.39) | NPSR1MAPTSLC6A4HTR3AHTR3E | |
| SCHEMBL3180342 | 0.80 | HTR3A (0.55) | SLC6A4HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL3180338 | 0.80 | HTR3A (0.55) | SLC6A4HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL9075220 | 0.80 | TNFSF11 (0.43) | — | |
| Fumaric Acid SCHEMBL9052111 | 0.79 | HTR3A (0.57) | SLC6A4HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL9048813 | 0.79 | MEN1 (0.45) | SLC6A4HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL9075286 | 0.77 | NPSR1 (0.37) | NPSR1BLMMAPTSLC6A4HTR3A | |
| Fumaric Acid SCHEMBL9051124 | 0.74 | HTR3A (0.46) | SLC6A4HTR3AHTR3EHTR3BHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0381422-B1 | Tetrahydrobenzimidazole derivatives | YAMANOUCHI PHARMA CO LTD (JP) | 1996-10-23 | — | — | EP | disclosed |
| EP-0381422-A1 | Tetrahydrobenzimidazole derivatives | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1990-08-08 | — | — | EP | disclosed |