Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8323681 | 0.87 | MAPT (0.49) | MAPTTP53THRBGAASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8330804 | 0.86 | MAPT (0.49) | MAPTTP53THRBGAASMN1; SMN2 | |
| SCHEMBL9541717 | 0.84 | MAPT (0.50) | MAPTTP53THRBGAASMN1; SMN2 | |
| SCHEMBL8323951 | 0.81 | MAPT (0.41) | MAPTTP53THRBHTR2CSMN1; SMN2 | |
| SCHEMBL8561030 | 0.79 | MAPT (0.56) | MAPTTP53THRBGAASMN1; SMN2 | |
| SCHEMBL8328461 | 0.79 | MAPT (0.52) | MAPTTP53THRBGAASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8625846 | 0.78 | MAPT (0.55) | MAPTTP53THRBGAASMN1; SMN2 | |
| SCHEMBL8327883 | 0.78 | MAPT (0.48) | MAPTTP53THRBGAASMN1; SMN2 | |
| SCHEMBL8322588 | 0.78 | ALDH1A1 (0.47) | MAPTIGF1RHTR2CALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL8328640 | 0.78 | MAPT (0.51) | MAPTTP53THRBGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705260-A1 | CONDENSED 4-AMINOPYRIDINES WITH ANTIRHEUMATIC ACTIVITY | KNOLL AKTIENGESELLSCHAFT (DE) | 1996-04-10 | — | — | EP | disclosed |