Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.54 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25313837 | 0.98 | ESR2 (0.53) | ESR2HCAR2RECQLSMN1; SMN2NPSR1 | |
| SCHEMBL3812522 | 0.98 | ESR2 (0.53) | ESR2HCAR2RECQLSMN1; SMN2NPSR1 | |
| SCHEMBL4687838 | 0.98 | ESR2 (0.53) | ESR2HCAR2RECQLSMN1; SMN2NPSR1 | |
| SCHEMBL25311256 | 0.98 | ESR2 (0.53) | ESR2HCAR2RECQLSMN1; SMN2NPSR1 | |
| SCHEMBL6093145 | 0.98 | ESR2 (0.53) | ESR2HCAR2RECQLSMN1; SMN2NPSR1 | |
| SCHEMBL1668850 | 0.96 | ESR2 (0.54) | ESR2HCAR2RECQLSMN1; SMN2NPSR1 | |
| SCHEMBL2502784 | 0.91 | — | — | |
| SCHEMBL13830556 | 0.84 | ESR2 (0.49) | ESR2HCAR2RECQLSMN1; SMN2NPSR1 | |
| SCHEMBL11239714 | 0.84 | HCAR2 (0.46) | ESR2HCAR2RECQLSMN1; SMN2HPGD | |
| SCHEMBL5154874 | 0.84 | ESR2 (0.55) | ESR2HCAR2RECQLSMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12612424-B2 | HPK1 inhibitors and uses thereof | REGOR PHARMACEUTICALS, INC. (US) | 2026-04-28 | — | — | US | disclosed |
| US-12545680-B2 | Substituted oxaspiro[4.5]decanes as mor receptor agonists | SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD. (CN) | 2026-02-10 | — | — | US | disclosed |
| CN-114555585-B | HPK1 inhibitors and uses thereof | 锐格药业公司 | 2025-02-11 | — | — | CN | disclosed |
| CN-113412263-B | Azabicyclo-substituted oxaspiro derivatives, preparation method and medical application thereof | 上海海雁医药科技有限公司 | 2024-07-26 | — | — | CN | disclosed |
| WO-2024137742-A1 | COMPOUNDS AND COMPOSITIONS AS FGFR3 DEGRADERS AND USES THEREOF | BLUEPRINT MEDICINES CORPORATION (US) | 2024-06-27 | — | — | WO | disclosed |
| US-20230128062-A1 | AZABICYCLIC SUBSTITUTED OXASPIRO DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD. (CN) | 2023-04-27 | — | — | US | disclosed |
| US-20230131899-A1 | INHIBITORS OF MICROBIALLY INDUCED AMYLOID | AXIAL THERAPEUTICS, INC. (US) | 2023-04-27 | — | — | US | disclosed |
| US-20230131899-A1 | INHIBITORS OF MICROBIALLY INDUCED AMYLOID | AXIAL THERAPEUTICS, INC. (US) | 2023-04-27 | — | — | US | disclosed |
| US-20230131899-A1 | INHIBITORS OF MICROBIALLY INDUCED AMYLOID | AXIAL THERAPEUTICS, INC. (US) | 2023-04-27 | — | — | US | disclosed |
| US-20230128062-A1 | AZABICYCLIC SUBSTITUTED OXASPIRO DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD. (CN) | 2023-04-27 | — | — | US | disclosed |
| US-20020019411-A1 | Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV and method | ASTRAZENECA AB (SE) | 2002-02-14 | — | — | US | disclosed |
| WO-2001068603-A2 | CYCLOPROPYL-FUSED PYRROLIDINE-BASED INHIBITORS OF DIPEPTIDYL IV, PROCESSES FOR THEIR PREPARATION, AND THEIR USE | BRISTOL-MYERS SQUIBB CO. (US) | 2001-09-20 | — | — | WO | disclosed |
| US-5559233-A | 3-/P-PHENYLBENZYL/IMIDAZOLONES AND PYRIMIDONES | SANOFI (FR) | 1996-09-24 | — | — | US | disclosed |
| US-5352788-A | Angiotensin antagonist | ELF SANOFI (FR) | 1994-10-04 | — | — | US | disclosed |
| US-5270317-A | N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present | ELF SANOFI (FR) | 1993-12-14 | — | — | US | disclosed |
| US-4338458-A | Cyclopentane derivatives useful as perfuming agents | FIRMENICH SA (CH) | 1982-07-06 | — | — | US | disclosed |
| US-4280934-A | Cyclopentane derivatives useful as perfuming agents | FIRMENICH SA (CH) | 1981-07-28 | — | — | US | disclosed |
| US-4206140-A | INSECTICIDES, ANTHELMINTICS | ROUSSEL UCLAF (FR) | 1980-06-03 | — | — | US | disclosed |
| US-4101574-A | Cyclopropanecarboxylic acid chlorides | ROUSSEL UCLAF (FR) | 1978-07-18 | — | — | US | disclosed |
| US-3997586-A | Cyclopropanecarboxylic acids and esters | ROUSSEL-UCLAF (FR) | 1976-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230131899-A1 | INHIBITORS OF MICROBIALLY INDUCED AMYLOID | SNCA, PARK7, PRNP | ESR2 4769/4885HCAR2 3112/4885RECQL 2540/4885 |
| US-12612424-B2 | HPK1 inhibitors and uses thereof | NEK11, NEK1, CSNK1A1 | ESR2 1861/4885HCAR2 686/4885RECQL 1836/4885 |
| US-12545680-B2 | Substituted oxaspiro[4.5]decanes as mor receptor agonists | OPRM1, OGFR, OPRL1 | ESR2 435/4885HCAR2 79/4885RECQL 4785/4885 |
| US-20230128062-A1 | AZABICYCLIC SUBSTITUTED OXASPIRO DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | CYP4A11, CYP51A1, CYP4F11 | ESR2 3242/4885HCAR2 362/4885RECQL 2720/4885 |
| US-20020019411-A1 | Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV and method | DPP4, DPP3, DPP7 | ESR2 2610/4885HCAR2 2696/4885RECQL 2347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.