Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 4/20 | 0.38 |
| ▸ | RARB | P10826 | 4/20 | 0.38 |
| ▸ | RARG | P13631 | 4/20 | 0.38 |
| ▸ | RXRA | P19793 | 2/20 | 0.36 |
| ▸ | HNF4A | P41235 | 1/20 | 0.36 |
| ▸ | MAP3K14 | Q99558 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.34 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 4/20 | 0.33 |
| ▸ | BACE1 | P56817 | 4/20 | 0.33 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9054621 | 0.93 | RARA (0.38) | RARARARBRARGRXRAHNF4A | |
| SCHEMBL8081756 | 0.79 | RARA (0.38) | RARARARBRARGRXRAHNF4A | |
| SCHEMBL6226479 | 0.76 | RARA (0.41) | RARARARBRARGRXRAHNF4A | |
| SCHEMBL6665611 | 0.76 | RARA (0.37) | RARARARBRARGRXRAHNF4A | |
| SCHEMBL9053578 | 0.76 | RARA (0.40) | RARARARBRARGRXRAHNF4A | |
| SCHEMBL330594 | 0.75 | CYP3A4 (0.44) | RARARARBRARGRXRACYP3A4 | |
| SCHEMBL29539383 | 0.75 | CYP3A4 (0.44) | RARARARBRARGRXRACYP3A4 | |
| SCHEMBL9053722 | 0.74 | RARA (0.48) | RARARARBRARGRXRAHNF4A | |
| SCHEMBL395807 | 0.74 | MAPT (0.44) | RARARARBRARGRXRAHNF4A | |
| SCHEMBL3344312 | 0.73 | ALDH1A1 (0.47) | CYP3A4TSHRMAPK1GRIA2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5498755-A | IMINE COMPOUNDS FOR SKIN DISORDERS AND ANTIINFLAMMATORY AGENTS | ALLERGAN, INC. | 1996-03-12 | — | — | US | disclosed |
| WO-1996006070-A1 | DISUBSTITUTED ARYL AND HETEROARYL IMINES HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN (US) | 1996-02-29 | — | — | WO | disclosed |