Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 8/20 | 0.42 |
| ▸ | RARG | P13631 | 8/20 | 0.42 |
| ▸ | RARA | P10276 | 8/20 | 0.42 |
| ▸ | RXRA | P19793 | 6/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | RXRG | P48443 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 3/20 | 0.38 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.37 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | GMNN | O75496 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9054854 | 0.88 | RARB (0.43) | RARBRARGRARARXRARXRB | |
| SCHEMBL9055440 | 0.84 | RARB (0.52) | RARBRARGRARARXRARXRB | |
| SCHEMBL9054413 | 0.82 | RARB (0.44) | RARBRARGRARARXRARXRB | |
| SCHEMBL9190924 | 0.80 | POLB (0.46) | RARBRARGRARARXRARXRB | |
| SCHEMBL9053667 | 0.80 | ALDH1A1 (0.52) | RARBRARGRARARXRACYP26A1 | |
| SCHEMBL9054417 | 0.78 | RARB (0.45) | RARBRARGRARARXRARXRB | |
| SCHEMBL9092406 | 0.77 | RARB (0.46) | RARBRARGRARARXRARXRB | |
| SCHEMBL10399252 | 0.73 | RXRA (0.56) | RARBRARGRARARXRARXRB | |
| SCHEMBL10399253 | 0.73 | RXRA (0.56) | RARBRARGRARARXRARXRB | |
| SCHEMBL6578573 | 0.71 | HDAC4 (0.55) | HDAC4HDAC6ALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5498755-A | IMINE COMPOUNDS FOR SKIN DISORDERS AND ANTIINFLAMMATORY AGENTS | ALLERGAN, INC. | 1996-03-12 | — | — | US | disclosed |
| WO-1996006070-A1 | DISUBSTITUTED ARYL AND HETEROARYL IMINES HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN (US) | 1996-02-29 | — | — | WO | disclosed |