Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11413259 | 0.88 | SMN1; SMN2 (0.69) | POLBCYP1A2CYP2C19ALDH1A1LMNA | |
| SCHEMBL11428179 | 0.83 | LMNA (0.68) | POLBGAALMNAMAPTSMN1; SMN2 | |
| SCHEMBL11418533 | 0.82 | POLB (0.52) | POLBTSHRCYP1A2CYP2C19CYP3A4 | |
| SCHEMBL9053644 | 0.82 | SMN1; SMN2 (0.78) | POLBGAATSHRALDH1A1LMNA | |
| SCHEMBL11221775 | 0.81 | MAPT (0.53) | POLBGAATSHRCYP1A2CYP2C19 | |
| Hydrochloric Acid SCHEMBL11233929 | 0.80 | MAPT (0.53) | POLBGAATSHRCYP1A2CYP2C19 | |
| SCHEMBL8423527 | 0.78 | MAPT (0.58) | POLBGAATSHRALDH1A1LMNA | |
| SCHEMBL9620133 | 0.78 | GAA (0.77) | POLBGAATSHRALDH1A1LMNA | |
| SCHEMBL7443824 | 0.78 | ITGB3 (0.71) | POLBGAAALDH1A1LMNAMAPT | |
| SCHEMBL4005240 | 0.78 | GAA (0.71) | POLBGAATSHRALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0528146-B1 | N-phenylthiourea derivatives and pharmaceutical use thereof | SANDOZ LTD (CH) | 1996-02-21 | — | — | EP | disclosed |
| EP-0528146-A1 | N-phenylthiourea derivatives and pharmaceutical use thereof | SANDOZ LTD. (CH) | 1993-02-24 | — | — | EP | disclosed |