Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | GPR84 | Q9NQS5 | 8/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | PPARG | P37231 | 6/20 | 0.40 |
| ▸ | PPARD | Q03181 | 6/20 | 0.40 |
| ▸ | PPARA | Q07869 | 6/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.40 |
| ▸ | TLR2 | O60603 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | FABP4 | P15090 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL905699 | 1.00 | TSHR (0.48) | TSHRLMNANFKB1PMP22GPR84 | |
| SCHEMBL1870547 | 1.00 | TSHR (0.48) | TSHRLMNANFKB1PMP22GPR84 | |
| SCHEMBL905720 | 1.00 | TSHR (0.48) | TSHRLMNANFKB1PMP22GPR84 | |
| SCHEMBL379359 | 1.00 | TSHR (0.48) | TSHRLMNANFKB1PMP22GPR84 | |
| SCHEMBL1230057 | 1.00 | TSHR (0.48) | TSHRLMNANFKB1PMP22GPR84 | |
| SCHEMBL290459 | 0.98 | LMNA (0.46) | TSHRLMNANFKB1PMP22GPR84 | |
| SCHEMBL34381 | 0.94 | TSHR (0.48) | TSHRLMNANFKB1PMP22GPR84 | |
| Ethylene Glycol SCHEMBL6523934 | 0.89 | TSHR (0.44) | TSHRLMNANFKB1PMP22GPR84 | |
| SCHEMBL43574 | 0.87 | EGLN1 (0.43) | TSHRLMNANFKB1PMP22ALDH1A1 | |
| SCHEMBL8405060 | 0.87 | TSHR (0.63) | TSHRLMNANFKB1PMP22GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2264065-B1 | NOVEL INSULIN DERIVATIVES | NOVO NORDISK AS (DK) | 2017-03-08 | — | — | EP | disclosed |
| US-20140349925-A1 | NOVEL INSULIN DERIVATIVES | NOVO NORDISK AS (DK) | 2014-11-27 | — | — | US | disclosed |
| US-8828923-B2 | Insulin derivatives | NOVO NORDISK A/S (DK) | 2014-09-09 | — | — | US | disclosed |
| EP-2275439-B1 | Novel insulin derivatives | NOVO NORDISK AS (DK) | 2014-03-26 | — | — | EP | disclosed |
| EP-2107069-B1 | Novel insulin derivatives | NOVO NORDISK AS (DK) | 2013-01-16 | — | — | EP | disclosed |
| EP-2287184-A2 | Novel insulin derivatives | NOVO NORDISK A/S (DK) | 2011-02-23 | — | — | EP | disclosed |
| EP-2275439-A2 | Novel insulin derivatives | NOVO NORDISK A/S (DK) | 2011-01-19 | — | — | EP | disclosed |
| EP-2264065-A2 | Novel Insulin Derivatives | NOVO NORDISK A/S (DK) | 2010-12-22 | — | — | EP | disclosed |
| EP-2264066-A2 | Novel insulin derivatives | NOVO NORDISK A/S (DK) | 2010-12-22 | — | — | EP | disclosed |
| US-20100009899-A1 | Novel Insulin Derivatives | NOVO NORDISK A/S (DK) | 2010-01-14 | — | — | US | disclosed |
| US-7615532-B2 | Antidiabetic agents; insulin derivatives which are naturally occurring insulins or analogues thereof which have a side chain attached either to the alpha-amino group of the N-terminal amino acid residue of the B chain or to epsilon-amino group of a Lys residue present in the B chain of parent insulin | NOVO NORDISK A/S (DE) | 2009-11-10 | — | — | US | disclosed |
| EP-2107069-A2 | Novel insulin derivatives | NOVO NORDISK A/S (DK) | 2009-10-07 | — | — | EP | disclosed |
| US-20060183668-A1 | Antidiabetic agents; insulin derivatives which are naturally occurring insulins or analogues thereof which have a side chain attached either to the alpha-amino group of the N-terminal amino acid residue of the B chain or to epsilon-amino group of a Lys residue present in the B chain of parent insulin | NOVO NORDISK A/S (DK) | 2006-08-17 | — | — | US | disclosed |
| EP-1660531-A2 | NOVEL INSULIN DERIVATIVES | NOVO NORDISK A/S (DK) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005012347-A2 | NOVEL INSULIN DERIVATIVES | NOVO NORDISK A/S (DK) | 2005-02-10 | — | — | WO | disclosed |