Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | POLB | P06746 | 4/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10590068 | 0.83 | CYP1A2 (0.40) | ALDH1A1POLBCYP1A2HTTTP53 | |
| SCHEMBL10590254 | 0.80 | HTT (0.40) | ALDH1A1POLBCYP1A2HTTTP53 | |
| Hydrochloric Acid SCHEMBL28359832 | 0.77 | POLB (0.49) | ALDH1A1POLBCYP1A2HTTTDP1 | |
| SCHEMBL6806145 | 0.76 | MAPT (0.38) | ALDH1A1POLBCYP1A2HTTTDP1 | |
| SCHEMBL9052781 | 0.76 | ALDH1A1 (0.41) | ALDH1A1TP53KMT2A | |
| SCHEMBL9903207 | 0.75 | POLB (0.36) | ALDH1A1POLBCYP1A2HTTTDP1 | |
| SCHEMBL1759003 | 0.75 | POLB (0.41) | ALDH1A1POLBCYP1A2HTTTDP1 | |
| SCHEMBL125329 | 0.75 | TDP1 (0.50) | ALDH1A1POLBCYP1A2HTTTP53 | |
| SCHEMBL125328 | 0.75 | TDP1 (0.50) | ALDH1A1POLBCYP1A2HTTTP53 | |
| SCHEMBL2557500 | 0.74 | ALDH1A1 (0.60) | ALDH1A1POLBCYP1A2HTTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510526-B1 | Use of sulfonamides as drug and new sulfonamides | HOFFMANN LA ROCHE (CH) | 1996-12-04 | — | — | EP | disclosed |
| EP-0510526-A1 | Use of sulfonamides as drug and new sulfonamides | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1992-10-28 | — | — | EP | disclosed |