Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
| ▸ | FBP1 | P09467 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 3/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1641897 | 0.77 | FBP1 (0.37) | POLBALDH1A1PDK1FBP1HTT | |
| SCHEMBL7977850 | 0.77 | ALDH1A1 (0.35) | POLBALDH1A1FBP1KMT2A | |
| SCHEMBL2298373 | 0.77 | FBP1 (0.37) | POLBALDH1A1PDK1FBP1HTT | |
| SCHEMBL3785484 | 0.76 | ALDH1A1 (0.42) | POLBALDH1A1PDK1FBP1HTT | |
| SCHEMBL4819823 | 0.76 | ALDH1A1 (0.35) | POLBALDH1A1FBP1SMN1; SMN2 | |
| SCHEMBL2300346 | 0.76 | ALDH1A1 (0.33) | POLBALDH1A1HTTL3MBTL1GAA | |
| SCHEMBL9054298 | 0.75 | ALDH1A1 (0.48) | POLBALDH1A1HTTL3MBTL1GAA | |
| SCHEMBL5530171 | 0.73 | GABRA1 (0.42) | MEN1KMT2A | |
| SCHEMBL8477971 | 0.72 | ALDH1A1 (0.36) | POLBALDH1A1PDK1FBP1HTT | |
| SCHEMBL1772317 | 0.71 | RIPK1 (0.43) | HTTLMNAMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981884-B1 | THIAZOLE COMPOUNDS AS PROTEIN KINASE B (PKB) INHIBITORS | AMGEN INC (US) | 2012-06-13 | — | — | EP | disclosed |