Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | PRCP | P42785 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7597072 | 0.80 | ALDH1A1 (0.49) | HTR2CHTR2AHTR2BCYP2D6HTR1A | |
| SCHEMBL7597067 | 0.80 | ALDH1A1 (0.49) | HTR2CHTR2AHTR2BCYP2D6HTR1A | |
| SCHEMBL8485673 | 0.76 | DRD3 (0.42) | HTR2CHTR2ASIGMAR1HTR1A | |
| SCHEMBL23032174 | 0.73 | GPR3 (0.58) | HTR2CHTR2ASIGMAR1ADRA1APRCP | |
| SCHEMBL5860592 | 0.70 | HTR2C (0.45) | HTR2CHTR2AHTR2BSIGMAR1PRCP | |
| SCHEMBL7517086 | 0.70 | HTR2C (0.38) | HTR2CHTR2AHTR2BHTR1AMEN1 | |
| SCHEMBL7517081 | 0.70 | HTR2C (0.38) | HTR2CHTR2AHTR2BHTR1AMEN1 | |
| SCHEMBL18716744 | 0.69 | HTR2A (0.49) | HTR2CHTR2ASIGMAR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL10598187 | 0.69 | HTR2C (0.45) | HTR2CHTR2AHTR2BPRCPTAAR1 | |
| SCHEMBL23173231 | 0.67 | SLC6A2 (0.32) | HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0673376-B1 | BICYCLIC PYRIMIDINE COMPOUNDS, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID COMPOUNDS | ADIR (FR) | 1996-05-22 | — | — | EP | disclosed |
| US-5508277-A | Bicyclic pyrimidines | ADIR ET COMPAGNIE (FR) | 1996-04-16 | — | — | US | disclosed |
| EP-0673376-A1 | NOVEL BICYCLIC PYRIMIDINE COMPOUNDS, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID COMPOUNDS. | ADIR (FR) | 1995-09-27 | — | — | EP | disclosed |
| WO-1994013668-A1 | NOVEL BICYCLIC PYRIMIDINE COMPOUNDS, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID COMPOUNDS | ADIR ET COMPAGNIE (FR) | 1994-06-23 | — | — | WO | disclosed |