SCHEMBL9054906

SCHEMBL9054906

Cc1c(SCCCSc2ccncc2)ccnc1CSc1ccccn1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.37
CYP1A2 P05177 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2D6 P10635 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
HIF1A Q16665 1/20 0.36
HPGD P15428 2/20 0.35
GRM2 Q14416 1/20 0.35
ALDH1A1 P00352 5/20 0.34
KDM4E B2RXH2 3/20 0.34
LMNA P02545 2/20 0.34
POLB P06746 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
NPC1 O15118 6/20 0.33
RAB9A P51151 6/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
ALOX15 P16050 1/20 0.33
HSD17B10 Q99714 1/20 0.33
MEN1 O00255 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7007914 0.88 GRM2 (0.37) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19
Hydrochloric Acid SCHEMBL7005188 0.84 MAPT (0.36) MAPTHPGDGRM2ALDH1A1KDM4E
SCHEMBL7009338 0.82 CYP1A2 (0.43) MAPTCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL7007419 0.80 GRM2 (0.33) GRM2
SCHEMBL7004086 0.78 POLB (0.50) MAPTHPGDALDH1A1LMNAPOLB
SCHEMBL7805086 0.78 RAB9A (0.54) MAPTCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL7007309 0.76 NPC1 (0.52) MAPTCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL7009360 0.76 SMN1; SMN2 (0.47) CYP2C9HPGDALDH1A1KDM4ENPC1
SCHEMBL7812340 0.76 NPC1 (0.54) MAPTCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL7011855 0.76 HSD17B10 (0.43) MAPTHPGDGRM2ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1996002505-A1 THIOPYRIDYL COMPOUNDS FOR CONTROLLING HELICOBACTER BACTERIA BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1996-02-01 WO disclosed