Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL766087 | 0.82 | CFTR (0.44) | POLBGAALMNAKMT2AMEN1 | |
| SCHEMBL10729129 | 0.80 | ALDH1A1 (0.44) | SMN1; SMN2POLBGAAKMT2AMEN1 | |
| SCHEMBL8097433 | 0.75 | MEN1 (0.44) | SMN1; SMN2POLBGAALMNAKMT2A | |
| SCHEMBL8103224 | 0.71 | MEN1 (0.44) | SMN1; SMN2POLBGAAKMT2AMEN1 | |
| SCHEMBL30058504 | 0.71 | MAPT (0.58) | HTTPOLBLMNAKMT2AMEN1 | |
| SCHEMBL8790062 | 0.70 | CFTR (0.41) | POLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL8427476 | 0.70 | HTT (0.47) | HTTGAAKMT2AMEN1MT-CO2 | |
| SCHEMBL11118838 | 0.68 | SMN1; SMN2 (0.63) | SMN1; SMN2HTTPOLBGAALMNA | |
| SCHEMBL9055178 | 0.65 | GAA (0.75) | SMN1; SMN2HTTGAALMNAKMT2A | |
| SCHEMBL8097540 | 0.64 | POLB (0.36) | SMN1; SMN2POLBGAAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0511558-B1 | Process for the resolution of racemates and associates of diastereoisomers | HOFFMANN LA ROCHE (CH) | 1996-10-23 | — | — | EP | claimed |
| US-5334766-A | Process for the resolution of racemic diphosphine oxides | HOFFMANN-LA ROCHE INC. (US) | 1994-08-02 | — | — | US | claimed |
| EP-0511558-A2 | Process for the resolution of racemates and associates of diastereoisomers | F. HOFFMANN-LA ROCHE AG (CH) | 1992-11-04 | — | — | EP | claimed |
| EP-0511558-B1 | Process for the resolution of racemates and associates of diastereoisomers | HOFFMANN LA ROCHE (CH) | 1996-10-23 | — | — | EP | disclosed |
| US-5334766-A | Process for the resolution of racemic diphosphine oxides | HOFFMANN-LA ROCHE INC. (US) | 1994-08-02 | — | — | US | disclosed |
| EP-0511558-A2 | Process for the resolution of racemates and associates of diastereoisomers | F. HOFFMANN-LA ROCHE AG (CH) | 1992-11-04 | — | — | EP | disclosed |