Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | ERN1 | O75460 | 5/20 | 0.36 |
| ▸ | KDM1A | O60341 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.33 |
| ▸ | CD44 | P16070 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA3 | P07451 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | CA6 | P23280 | 1/20 | 0.32 |
| ▸ | CA5A | P35218 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.32 |
| ▸ | FADS1 | O60427 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17603206 | 0.94 | TDP1 (0.38) | GAATDP1ERN1KDM1ACA1 | |
| SCHEMBL2307383 | 0.84 | GAA (0.46) | GAATDP1ERN1CA1CA2 | |
| SCHEMBL3197190 | 0.81 | ERN1 (0.41) | TDP1ERN1CA1CA2CA9 | |
| SCHEMBL604322 | 0.79 | TDP1 (0.43) | TDP1ERN1KDM1AKDM1BALDH1A1 | |
| SCHEMBL30207763 | 0.79 | TDP1 (0.48) | TDP1ERN1KDM1AKDM1BALDH1A1 | |
| SCHEMBL8672712 | 0.79 | TDP1 (0.48) | TDP1ERN1KDM1AKDM1BALDH1A1 | |
| SCHEMBL6187165 | 0.77 | TDP1 (0.46) | TDP1ERN1KDM1AKDM1BALDH1A1 | |
| SCHEMBL31618920 | 0.77 | TDP1 (0.41) | TDP1ERN1KDM1AKDM1BALDH1A1 | |
| SCHEMBL1972414 | 0.77 | TDP1 (0.41) | TDP1ERN1KDM1AKDM1BALDH1A1 | |
| SCHEMBL32659849 | 0.77 | ERN1 (0.41) | GAATDP1ERN1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-8283217-A | — | — | None | — | — | JP | disclosed |
| US-12103921-B2 | Chemical compounds | PFIZER INC. (US) | 2024-10-01 | — | — | US | disclosed |
| US-20230391763-A1 | MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY | EVOTEC INTERNATIONAL GMBH (DE) | 2023-12-07 | — | — | US | disclosed |
| US-20230382892-A1 | Chemical Compounds | PFIZER INC. (US) | 2023-11-30 | — | — | US | disclosed |
| CN-116761803-A | Modulators of integrated stress response pathways | 埃沃特克国际有限责任公司 | 2023-09-15 | — | — | CN | disclosed |
| EP-4232447-A1 | MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY | Evotec International GmbH (DE) | 2023-08-30 | — | — | EP | disclosed |
| US-11702405-B2 | Chemical compounds | PFIZER INC. (US) | 2023-07-18 | — | — | US | disclosed |
| US-20220348555-A1 | Chemical Compounds | PFIZER INC. (US) | 2022-11-03 | — | — | US | disclosed |
| WO-2022084447-A1 | MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY | EVOTEC INTERNATIONAL GMBH (DE) | 2022-04-28 | — | — | WO | disclosed |
| WO-2022084447-A1 | MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY | EVOTEC INTERNATIONAL GMBH (DE) | 2022-04-28 | — | — | WO | disclosed |
| US-9303028-B2 | Azetidine and piperidine compounds useful as PDE10 inhibitors | AMGEN INC. (US) | 2016-04-05 | — | — | US | disclosed |
| EP-2864317-A1 | AZETIDINE AND PIPERIDINE COMPOUNDS USEFUL AS PDE10 INHIBITORS | AMGEN, INC. (US) | 2015-04-29 | — | — | EP | disclosed |
| US-20140148435-A1 | AZETIDINE AND PIPERIDINE COMPOUNDS USEFUL AS PDE10 INHIBITORS | AMGEN INC. (US) | 2014-05-29 | — | — | US | disclosed |
| US-20140148435-A1 | AZETIDINE AND PIPERIDINE COMPOUNDS USEFUL AS PDE10 INHIBITORS | AMGEN INC. (US) | 2014-05-29 | — | — | US | disclosed |
| US-20140148435-A1 | AZETIDINE AND PIPERIDINE COMPOUNDS USEFUL AS PDE10 INHIBITORS | AMGEN INC. (US) | 2014-05-29 | — | — | US | disclosed |
| US-8691986-B2 | Azetidine and piperidine compounds useful as PDE10 inhibitors | AMGEN INC. (US) | 2014-04-08 | — | — | US | disclosed |
| US-8691986-B2 | Azetidine and piperidine compounds useful as PDE10 inhibitors | AMGEN INC. (US) | 2014-04-08 | — | — | US | disclosed |
| WO-2013188724-A1 | AZETIDINE AND PIPERIDINE COMPOUNDS USEFUL AS PDE10 INHIBITORS | AMGEN INC. (US) | 2013-12-19 | — | — | WO | disclosed |
| US-20130338138-A1 | AZETIDINE AND PIPERIDINE COMPOUNDS USEFUL AS PDE10 INHIBITORS | AMGEN INC. | 2013-12-19 | — | — | US | disclosed |
| JP-H08283217-A | 4,5-DIHALOANILINE DERIVATIVE AND ITS PRODUCTION | UBE IND LTD | 1996-10-29 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11702405-B2 | Chemical compounds | HBZ, HBB, HBS1L | GAA 672/4885TDP1 1597/4885ERN1 2434/4885 |
| US-20230382892-A1 | Chemical Compounds | HBZ, HBB, HBS1L | GAA 672/4885TDP1 1597/4885ERN1 2434/4885 |
| US-20230391763-A1 | MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY | CRH, AVPR1B, CRHR2 | GAA 3152/4885TDP1 1775/4885ERN1 1516/4885 |
| US-20140148435-A1 | AZETIDINE AND PIPERIDINE COMPOUNDS USEFUL AS PDE10 INHIBITORS | PDE10A, PDE9A, PDE2A | GAA 158/4885TDP1 127/4885ERN1 4157/4885 |
| US-20130338138-A1 | AZETIDINE AND PIPERIDINE COMPOUNDS USEFUL AS PDE10 INHIBITORS | PDE10A, PDE9A, PDE2A | GAA 158/4885TDP1 127/4885ERN1 4157/4885 |
| US-12103921-B2 | Chemical compounds | HBZ, HBB, HBS1L | GAA 672/4885TDP1 1597/4885ERN1 2434/4885 |
| US-20220348555-A1 | Chemical Compounds | HBZ, HBB, HBS1L | GAA 672/4885TDP1 1597/4885ERN1 2434/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.