Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | HTT | P42858 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | EDNRA | P25101 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6782598 | 0.81 | ADRA1A (0.54) | ALDH1A1HTTSMN1; SMN2ADRA2AADRA2B | |
| SCHEMBL6784680 | 0.75 | ADRA1A (0.56) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL8594288 | 0.68 | ADRA1D (0.58) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL6718413 | 0.67 | ADRA1D (0.68) | ADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL6767632 | 0.67 | ADRA1D (0.67) | ADRA1DADRA1AADRA1B | |
| SCHEMBL3525700 | 0.66 | CFB (0.32) | — | |
| SCHEMBL5466528 | 0.63 | TMEM97 (0.63) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL9055571 | 0.63 | SCN1A (0.44) | ALDH1A1HTTSMN1; SMN2KDM4ETSHR | |
| SCHEMBL880189 | 0.62 | GPBAR1 (0.80) | HTTPKM | |
| SCHEMBL7953726 | 0.62 | ADRA1D (0.56) | ALDH1A1HTTSMN1; SMN2KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996014846-A1 | DIHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1996-05-23 | — | — | WO | disclosed |