Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9398319 | 0.74 | MAPT (0.36) | MAPTLMNAHTTNPC1POLB | |
| SCHEMBL1801055 | 0.73 | GAA (0.42) | MAPTLMNAHTTNPC1POLB | |
| SCHEMBL8097979 | 0.68 | GABRA1 (0.51) | MAPTLMNAHTTNPC1POLB | |
| SCHEMBL5831194 | 0.66 | GABRA1 (0.52) | MAPTLMNAMAPK1GABRA1GABRB2 | |
| SCHEMBL429173 | 0.65 | NPC1 (0.45) | MAPTLMNAHTTNPC1POLB | |
| SCHEMBL2163311 | 0.65 | MAPT (0.40) | MAPTLMNAHTTNPC1POLB | |
| SCHEMBL5010980 | 0.64 | GABRA1 (0.54) | MAPTLMNAPOLBMAPK1GABRA1 | |
| SCHEMBL3253183 | 0.64 | ALDH1A1 (0.48) | MAPTLMNAHTTKDM4EGAA | |
| SCHEMBL10835909 | 0.64 | DAO (0.38) | MAPTGABRA1GABRB2TDP1KDM4E | |
| SCHEMBL3660175 | 0.64 | GABRA1 (0.46) | MAPTLMNAHTTNPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0515535-A4 | ANGIOTENSIN II ANTAGONISTS INCORPORATING A SUBSTITUTED BENZYL ELEMENT | MERCK & CO INC (US) | 1996-01-17 | — | — | EP | disclosed |